The rise and fall of infectious diseases: Australian perspectives, 1914-2014.

Australia has been fortunate in its experience with infectious diseases over the past century. By the 1960s, many communicable diseases were controlled through a combination of high living standards, progressive adoption of vaccines and antimicrobial treatment. Australian medical scientists have made substantial contributions to the understanding of many historically significant communicable diseases and global initiatives for control.

Parvovirus B19 infection and severe anaemia in Kenyan children: a retrospective case control study.

Background: During acute Human parvovirus B19 (B19) infection a transient reduction in blood haemoglobin concentration is induced, due to a 5-7 day cessation of red cell production. This can precipitate severe anaemia in subjects with a range of pre-existing conditions. Of the disease markers that occur during B19 infection, high IgM levels occur closest in time to the maximum reduction in haemoglobin concentration.

The early host innate immune response to duck hepatitis B virus infection.

The early phase after hepatitis B virus infection could play a crucial role in clearance and/or persistence of the virus, particularly in neonates. This work compared the early phase of duck hepatitis B virus infection in 1-day-old (D1) and 28-day-old (D28) ducks to determine whether differences in viral or host innate immune response can be related to the difference in outcome. In the first phase, almost immediately after inoculation, virus was taken up by components of the reticulo-endothelial systems, particularly liver-specific macrophages, Kupffer cells.

Hepatitis C virus infection rates and risk factors in an Australian hospital endoscopy cohort.

Objective: To determine the reservoir and risk factors of HCV infection in a hospital population.

Methods: The presence of anti-HCV in 2,119 endoscopy patients was related to putative risk factors for exposure using the SAS statistical package.

Results: Most of the 4.

The effect of multiple cycles of contamination, detergent washing, and disinfection on the development of biofilm in endoscope tubing.

Background: Patient soil and bacterial biofilm in patient-ready endoscope channels can adversely impact the efficacy of detergent and disinfectant, thereby increasing the risk of nosocomial infection. Biofilm bacteria are firmly attached to one another and to the substrate by exopolysaccharide, making them difficult to remove. We analyzed the effect of 20 wash/contamination cycles on biofilm formation.