Publications by authors named "Y E Chern"
Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA.
View Article and Find Full Text PDFBackground: Many surgeons have begun learning about colorectal surgery using laparoscopy rather than laparotomy. The domains of four-step technique training program (DOF) for laparoscopic colorectal surgery have been designed and implemented by our institute since 2011, and they are expected to provide a safe and effective program for trainees with limited experience in laparoscopic colorectal surgery.
Method: The DOF were established with standard surgical procedures, a four-step technique, and learning passports using point credits after the procedure was completed.
Article Synopsis
- Hypermetabolism is common in ALS patients, and abnormal AMPK activation, linked to adiponectin, disrupts TDP-43 localization, a key factor in ALS development.
- The study found higher plasma adiponectin levels in ALS patients with lower clinical severity scores (ALSFRS-R) and a negative correlation between adiponectin and these scores.
- Results indicated that adiponectin activates AMPK and causes TDP-43 mislocalization in motor neurons, suggesting an important role of the adiponectin-AMPK-TDP-43 pathway in ALS-related energy imbalances.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of HTT exon 1. HD is characterized by progressive neurodegeneration and metabolic abnormalities, particularly in the brain, which accounts for approximately 20 % of the body's resting metabolic rate. Dysregulation of energy homeostasis in HD includes impaired glucose transporters, abnormal functions of glycolytic enzymes, changes in tricarboxylic acid (TCA) cycle activity and enzyme expression in the basal ganglia and cortical regions of both HD mouse models and HD patients.
View Article and Find Full Text PDF