Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial.

Background: A broad-spectrum anti-SARS-CoV-2 monoclonal antibody (mAb), SA55, is highly effective against SARS-CoV-2 variants. This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, and immunogenicity of the SA55 nasal spray in healthy individuals.

Methods: This phase I, dose-escalation clinical trial combined an open-label design with a randomized, controlled, double-blind design.

Anti-Fatigue Activity of Corn Protein Hydrolysate Fermented by Lactic Acid Bacteria.

Objectives: This study aimed to clarify the effect of lactic acid bacteria-fermented corn protein hydrolysate (FCH) on fatigue in mice and explore the connection between fatigue-related indicators and intestinal microbial flora.

Methods: The fatigue model of mice was constructed by exercise endurance experiment. The anti-fatigue level of FCH was evaluated by measuring physiological and biochemical indexes in mouse serum, liver and skeletal muscle.

Multi-Structure-Based Refractive Index Sensor and Its Application in Temperature Sensing.

In this paper, a new sensor structure is designed, which consists of a metal-insulator-metal (MIM) waveguide and a circular protrusion and a rectangular triangular cavity (CPRTC). The characterization of nanoscale sensors is considered using an approximate numerical method (finite element method). The simulation results show that the sharp asymmetric resonance generated by the interaction between the discrete narrow-band mode and the continuous wideband mode is called Fano resonance.

Human-Centric Spatial Cognition Detecting System Based on Drivers' Electroencephalogram Signals for Autonomous Driving.

Existing autonomous driving systems face challenges in accurately capturing drivers' cognitive states, often resulting in decisions misaligned with drivers' intentions. To address this limitation, this study introduces a pioneering human-centric spatial cognition detecting system based on drivers' electroencephalogram (EEG) signals. Unlike conventional EEG-based systems that focus on intention recognition or hazard perception, the proposed system can further extract drivers' spatial cognition across two dimensions: relative distance and relative orientation.

Recent Progress in Enzyme Immobilization to Metal-Organic Frameworks to Enhance the CO Conversion Efficiency.

Climate change and the energy crisis, driven by excessive CO emissions, have emerged as pressing global challenges. The conversion of CO into high-value chemicals not only mitigates atmospheric CO levels but also optimizes carbon resource utilization. Enzyme-catalyzed carbon technology offers a green and efficient approach to CO conversion.