Interrelated approach to optimization of biosynthesis and chemical isolation of biologically active substances: the production of penicillinamidase by Escherichia coli and peptidohydrolase by Xanthomonas sp.

The solution to the problem of optimizing conditions for the isolation of biologically active substances (BAS) from microbial cells should be based on investigations of the structural and functional characteristics of cultures. Models of two bacterial cultures, of Escherichia coli and a Xanthomonas species, producing enzymes the localization of which differ, is described. The isolation of membrane-bound penicillinamidase from E.