Publications by authors named "Y Dion"
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the genetic basis of Tourette's syndrome through a genome-wide association study (GWAS) involving a large sample of case subjects and controls to identify shared genetic factors and predict tic severity.
- A significant genetic association was found with the FLT3 gene on chromosome 13, but it was not confirmed in a follow-up study; nonetheless, most of the heritability was linked to genetic variants in conserved regions.
- The findings suggest that genetic risk scores for Tourette's are linked to the severity of tics and are higher in individuals with a family history of tic disorders, indicating a potential genetic influence on the manifestation of the syndrome.
Triticale (x Wittmack) is an important feed crop which suffers severe yield, grade and end-use quality losses due to head blight (FHB). Development of resistant triticale cultivars is hindered by lack of effective genetic resistance sources. To dissect FHB resistance, a doubled haploid spring triticale population produced from the cross TMP16315/AC Ultima using a microspore culture method, was phenotyped for FHB incidence, severity, visual rating index (VRI), deoxynivalenol (DON) and some associated traits (ergot, grain protein content, test weight, yield, plant height and lodging) followed by single nucleotide polymorphism (SNP) genotyping.
View Article and Find Full Text PDFPrevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.
Eur Child Adolesc Psychiatry
May 2018
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study.
View Article and Find Full Text PDFBackground: The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families.
Method: OCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class analyses (LCA) of the resulting OCD and ADHD factor sum scores jointly; heritability and clinical relevance of the resulting factors and classes were assessed.