Publications by authors named "Y Dal Bosco"
The treatment landscape for Rheumatoid Arthritis (RA) has evolved significantly with the introduction of Janus kinase inhibitors (JAKi), such as Tofacitinib (TOFA), which offer a new therapeutic option for patients who have failed or are intolerant to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Safety concerns, particularly related to cardiovascular and cancer risks, prompted a need for additional investigation in real-world clinical settings. This study aimed to evaluate the long-term effectiveness and predictors of response to TOFA in two subpopulations of RA patients, categorized by differing cardiovascular risk profiles.
View Article and Find Full Text PDFArticle Synopsis
- Autoimmune systemic diseases (ASD) patients exhibit reduced immunogenic response to COVID-19 vaccines compared to age-matched controls, even after receiving booster doses.
- In a study involving 478 ASD patients, antibody levels after vaccination significantly increased post-booster, but still remained lower than those of control participants.
- After booster vaccination, the proportion of ASD patients showing absent or suboptimal vaccine response dropped notably, yet a significant percentage (7.8%) still lacked effective seroconversion, highlighting the need for ongoing monitoring.
Article Synopsis
- Autoimmune systemic diseases (ASD) increase the likelihood of contracting COVID-19, with a study of nearly 4,000 Italian ASD patients revealing a higher infection rate compared to the general population.
- While ASD patients had more cases of COVID-19, their death rate was similar to that of the overall Italian population, though systemic sclerosis patients faced a higher risk of mortality.
- Key factors influencing the severity of COVID-19 in ASD patients included older age, male gender, and certain medical treatments, with those on specific medications showing a significantly lower infection prevalence.
Background: Systemic sclerosis (SSc) is a chronic autoimmune disease that is characterized by vasculopathy and fibrosis of the skin and visceral organs. Heart valve diseases are poorly described and generally not considered typical of SSc. We aimed to describe valvular abnormalities in a multicenter cohort of SSc patients and to investigate their correlation with SSc features.
View Article and Find Full Text PDFVersican is an extracellular matrix proteoglycan that has been identified as a modulator of adhesion loss, cell motility, and tumour progression. This motility results from the interaction between versican and cell surface receptors. Studies have also demonstrated the relationship between this molecule and invasion in canine mammary tumours.
View Article and Find Full Text PDF