Gait-based Parkinson's disease diagnosis and severity classification using force sensors and machine learning.

A dual-stage model for classifying Parkinson's disease severity, through a detailed analysis of Gait signals using force sensors and machine learning approaches, is proposed in this study. Parkinson's disease is the primary neurodegenerative disorder that results in a gradual reduction in motor function. Early detection and monitoring of the disease progression is highly challenging due to the gradual progression of symptoms and the inadequacy of conventional methods in identifying subtle changes in mobility.

Palladium-Catalyzed Intramolecular C-H Amination via Oxidative Coupling on Indole Derivatives: Access to 11-Benzo[4,5]imidazo[1,2-]indoles.

A novel palladium-catalyzed intramolecular C-H amination via oxidative coupling exploiting inactivated N-substituted aryl amines on indoles for the one-pot synthesis of novel 11-benzo[4,5]imidazo[1,2-]indole derivatives is reported. The optimized reaction conditions accommodated a wide range of electronic variations on both the indole and the pendant aryl amine ring, resulting in products with good to excellent yields.

Google trend analysis of the Indian population reveals a panel of seasonally sensitive comorbid symptoms with implications for monitoring the seasonally sensitive human population.

Seasonal variations in the environment induce observable changes in the human physiological system and manifest as various clinical symptoms in a specific human population. Our earlier studies predicted four global severe seasonal sensitive comorbid lifestyle diseases (SCLDs), namely, asthma, obesity, hypertension, and fibrosis. Our studies further indicated that the SCLD category of the human population may be maladapted or unacclimatized to seasonal changes.

Respiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: A systematic review and meta-analysis.

Several epidemiological studies have examined the respiratory consequences of occupational exposure to volatile organic compounds (VOCs). However, their effects on paint industry workers in organised and unorganised occupational sectors vary. The present systematic review and meta-analysis aim at evaluating the respiratory symptoms and pulmonary function of paint industry workers from various occupational sectors exposed to VOCs.