Publications by authors named "Y D Sarathkumara"
Article Synopsis
- Epstein-Barr virus (EBV) is linked to various types of lymphomas, and while EBV-specific T-cell (EBVST) therapies have shown effectiveness, not all patients benefit from them.
- A study analyzing immune responses in 56 lymphoma patients receiving EBVST treatments discovered distinct antibody profiles that differentiate responders from non-responders, particularly at 3 months after treatment.
- The research identified 10 specific IgG antibodies that can predict clinical responses, suggesting that these EBV-directed antibodies may serve as biomarkers for patient outcomes in EBV-associated lymphoma treatments.
Article Synopsis
- Epstein-Barr virus (EBV) is linked to classical Hodgkin lymphoma (cHL), but the role of antibodies against EBV in cHL patients isn't fully understood, prompting a study to investigate this connection.
- Researchers conducted a custom protein microarray study comparing antibody responses in EBV-positive cHL patients from East Asia with healthy controls, discovering a specific antibody profile unique to this population.
- The study found that a majority of these antibodies were also associated with cHL in a separate European population, indicating that certain EBV antibodies may serve as reliable biomarkers for EBV-positive cHL across different demographics.
Article Synopsis
- The study evaluates the stability of twelve commonly used reference genes in RTqPCR analysis following Plasmodium yoelii sporozoite challenge and immunization in mice.
- It found significant expression changes in six of these genes due to the parasite challenge or immunization, indicating that not all reference genes are suitable for this type of analysis.
- SDHA and TBP were identified as stable reference genes, leading to the development of a robust RTqPCR protocol that can improve the consistency and reliability of malaria vaccine efficacy studies across different research settings.
Background: Epstein-Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL).
Methods: Anti-EBV IgG and IgA antibody responses targeting 202 sequences from 86 EBV proteins were measured using the same EBV whole proteome array across four case-control studies investigating EBV-positive cHL, eBL, NPC, and NKTCL (407 cases/620 controls). We grouped EBV-targeted antibodies into pathways by immunoglobulin type (IgA and IgG) and life-cycle stage (latent, immediate early lytic, early lytic, late lytic, and glycoprotein) and evaluated their association with each cancer type.
Chronic kidney disease of unknown aetiology (CKDu) is a major public health problem in Sri Lanka, especially among agrarian communities. Although the cause of CKDu is still unknown, hantavirus infection has been proposed as a risk factor. This study was performed using serological samples collected from two CKDu-endemic areas, Anuradhapura (2010) and Badulla districts (2010 and 2016), and a non-endemic area, Matale (2016) district.
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