Publications by authors named "Y D'Agostino"
The nasopharyngeal tract contains a complex microbial community essential to maintaining host homeostasis. Recent studies have shown that SARS-CoV-2 infection changes the microbial composition of the nasopharynx. Still, little is known about how it affects the fungal microbiome, which could provide valuable insights into disease pathogenesis.
View Article and Find Full Text PDFSmall non-coding RNAs (sncRNAs) make up ~1% of the transcriptome; nevertheless, they play significant roles in regulating cellular processes. Given the complexity of the central nervous system, sncRNAs likely hold particular importance in the human brain. In this study, we provide sncRNA transcriptomic profiles in a range of adult and prenatal brain regions, with a focus on piRNAs, due to their underexplored expression in somatic cells and tissue-specific nature.
View Article and Find Full Text PDFArticle Synopsis
- Advanced molecular biology techniques, including endomyocardial biopsy, are enhancing the diagnosis of cardiomyopathies in dogs, especially through studies of living animals.
- In a study of nine dogs with dilated cardiomyopathy, histologic and genetic analyses revealed various types of inflammation and viral infections, along with altered gene-expression pathways compared to healthy controls.
- The findings suggest that next-generation sequencing can uncover critical molecular and genetic factors involved in the development and progression of dilated cardiomyopathy in dogs.
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people worldwide and has significant implications for public health. Host transcriptomics profiling provides comprehensive understanding of how the virus interacts with host cells and how the host responds to the virus. COVID-19 disease alters the host transcriptome, affecting cellular pathways and key molecular functions.
View Article and Find Full Text PDF