Publications by authors named "Y Compta"
Article Synopsis
- A novel α-synuclein seed amplification assay (synSAA) was developed to differentiate misfolded α-synuclein seeds linked to multiple system atrophy (MSA) and Parkinson's disease (PD).
- The study analyzed cerebrospinal fluid (CSF) and brain samples from various clinical cohorts across multiple medical centers to assess the assay's diagnostic accuracy.
- Findings showed that brain samples with Lewy bodies were positive for synSAA, indicating potential for the assay in distinguishing between MSA and PD in diagnostic settings.
Disease associated pathological aggregates of alpha-synuclein (αSynD) exhibit prion-like spreading in synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Seed amplification assays (SAAs) such as real-time quaking-induced conversion (RT-QuIC) have shown high diagnostic sensitivity and specificity for detecting proteopathic αSynD seeds in a variety of biospecimens from PD and DLB patients. However, the extent to which relative proteopathic seed concentrations are useful as indices of a patient's disease stage or prognosis remains unresolved.
View Article and Find Full Text PDFImpulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.
View Article and Find Full Text PDFArticle Synopsis
- Wasteosomes (or corpora amylacea) are polyglucosan bodies linked to aging and neurodegenerative diseases, potentially serving a brain cleaning function.
- A study examined wasteosomes in 124 post-mortem FTLD patients across three proteinopathies (tau, TDP, and FUS), finding a higher accumulation in FTLD patients compared to controls, particularly in FTLD-FUS cases.
- Results indicated that while wasteosomes increased with disease duration in FTLD-TDP, they did not show this trend in FTLD-tau and FTLD-FUS, suggesting varying roles in disease progression among the proteinopathies.