Publications by authors named "Y Cigremis"
Acrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in fried and baked carbohydrate-rich foods. ACR is regarded as a typical axonal neurotoxin that induces neuropathy.
View Article and Find Full Text PDFAcrylamide (ACR) is a toxic chemical frequently encountered in daily life, posing health risks. This study aimed to elucidate the molecular-level mechanism of ACR's toxic effects on testicles and investigate whether Vitamin E can mitigate these effects. A total of 40 adult pregnant rats were utilized, divided into four groups: Control, ACR, Vitamin E, and ACR + Vitamin E.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the impact of TRPV1 channels on Alzheimer's Disease (AD), focusing on how capsaicin (a TRPV1 agonist) and capsazepine (a TRPV1 antagonist) affect neurodegeneration and memory in a rat model induced by okadaic acid.
- - Administering okadaic acid increased harmful brain markers and led to impaired spatial memory, while capsaicin treatment reversed these negative effects, unlike capsazepine, which did not show similar benefits.
- - The findings suggest that capsaicin can help alleviate neurodegeneration and inflammation in an AD model, potentially highlighting the therapeutic role of TRPV1 activation in cognitive decline.
Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity.
Eur Rev Med Pharmacol Sci
October 2022
Objective: This study was performed to investigate the potential beneficial effects of thymoquinone (TQ) on brain tissue based on biochemical and histopathological analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity.
Materials And Methods: The rats were randomly divided into 4 groups with 8 rats in each group (n:8). Group 1: (Control), saline was administered for 3 days at a volume of 0.