Publications by authors named "Y Chorfi"
Microbial biotransformation of Zearalenone (ZEN) is a promising deactivation approach. The residual toxicity and stability of Zearalenone-14-phosphate (ZEN-14-P) and Zearalenone-16-phosphate (ZEN-16-P), two novel microbial phosphorylation products of ZEN, remain unknown. We investigated the cytotoxicity, oxidative stress, proinflammatory, and estrogenic activity of phosphorylated ZENs using porcine intestinal cells, uterine explants, and human endometrial cells and traced their metabolic fate by liquid chromatography-tandem mass spectrometry (LC-MS)/MS analysis.
View Article and Find Full Text PDFZero-valent copper and silver metals (Ms) nanoparticles (NPs) supported on carboxymethylcellulose (CMC) were synthesized for treating Enterotoxigenic fimbriae 4 (ETEC:F4), a major cause of diarrhea in post-weaned pigs. The antibacterial properties of Cu/CMC and Ag/CMC were assessed on infected porcine intestinal enterocyte IPEC-J2, an in vitro model mimicking the small intestine. The lower average particle size (218 nm) and polydispersity index [PDI]: 0.
View Article and Find Full Text PDFEach year ∼150,000 surplus calves are sold at auction markets in Québec, Canada. Surplus calves (male or female not kept in the herd of origin) are sold at a young age, but these animals are at risk of receiving lower quality neonatal care than replacement heifers. Knowledge of factors associated with a higher selling price could help convince farmers to spend more resources in the care surplus calves.
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- Feeding pigs low-quality grains can lead to mycotoxin contamination, specifically deoxynivalenol (DON), which causes health issues like reduced appetite, inflammation, and oxidative stress.
- A study examined the effects of adding vitamin 25(OH)D, vitamin E, and vitamin C to the diets of pigs exposed to DON, showing that these vitamins could enhance immune functions and mitigate the negative impacts of DON.
- Results indicated that the combination of these vitamins improved the pigs’ antioxidant defenses, reduced inflammation, and restored vitamin D status, ultimately helping to counteract the harmful effects associated with DON after an immune challenge.
Conjugation of carbohydrates to nanomaterials has been extensively studied and recognized as an alternative in the biomedical field. Dendrimers synthesized with mannose at the end group and with entrapped zero-valent copper/silver could be a potential candidate against bacterial proliferation. This study is aimed at investigating the bactericidal activity of metal-glycodendrimers.
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