Publications by authors named "Y Chhabra"
Background And Aims: Isocitrate dehydrogenase 1 ( IDH1 )-mutant cholangiocarcinoma (CCA) is a highly lethal subtype of hepatobiliary cancer that is often resistant to immune checkpoint inhibitor therapies. We evaluated the effects of IDH1 mutations in CCA cells on the tumor immune microenvironment and identified opportunities for therapeutic intervention.
Approach And Results: Analysis of 2606 human CCA tumors using deconvolution of RNA-sequencing data identified decreased CD8+ T cell and increased M2-like tumor-associated macrophage (TAM) infiltration in IDH1 -mutant compared to IDH1 wild-type tumors.
Backgrounds And Aims: This study explores the impact of allograft selection in revision ACL reconstruction (RACLR). Allografts reduce donor-site morbidity and surgery duration but are costly and may prolong graft integration times. We aimed to assess various allograft subtypes for their efficacy and failure rates in RACLR.
View Article and Find Full Text PDFIn rodents, loss of growth hormone (GH) or its receptor is associated with extended lifespan. We aimed to determine the signaling process resulting in this longevity using GH receptor (GHR)-mutant mice with key signaling pathways deleted and correlate this with cancer incidence and expression of genes associated with longevity. GHR uses both canonical janus kinase (JAK)2-signal transducer and activator of transcription (STAT) signaling as well as signaling via the LYN-ERK1/2 pathway.
View Article and Find Full Text PDFArticle Synopsis
- Advancing age makes it harder for people to fight skin melanoma, a type of skin cancer.
- Scientists found that tiny particles called extracellular vesicles (EVs) from older cells change in content, even though they look the same as those from younger cells.
- A special protein called CD9 decreases as we age, which affects how these EVs can help tumors grow, making older cells better at supporting cancer.
Article Synopsis
- Cutaneous melanoma shows a notable sex disparity in how often it occurs and affects different genders, particularly worsening with age, but the reasons behind this are not fully understood.* -
- The study reveals that skin fibroblasts from older males experience changes that lead to increased melanoma cell invasiveness and resistance to treatment, impacting the behavior of tumors in older male mice.* -
- A specific protein, BMP2, is linked to the more aggressive characteristics of melanoma cells in aged males, and blocking its action can make these cancer cells more responsive to certain treatments.*