Publications by authors named "Y Castier"
Background: Incidental lung cancer, in the field of lung transplantation (LTx), is more often related to malignancies diagnosed in explants or transplanted organs. Little is known about cancer diagnosed during the medical evaluation of potential LTx candidates. What are the clinical, and prognostic differences between lung cancers diagnosed before or after transplantation in LTx candidates?
Methods: We performed a retrospective, observational, single-center study to describe the characteristics of lung malignancies first discovered during the pre-transplant assessment and then identified in lung explants, over the same period.
FGF21 Signaling Exerts Anti-Fibrotic Properties During Pulmonary Fibrosis.
Am J Respir Crit Care Med
December 2024
Rationale: Idiopathic Pulmonary Fibrosis (IPF) is a lethal disease with limited therapeutic options. FGF21, an endocrine fibroblast growth factor that acts through the FGFR1/KLB pathway, mitigates liver fibrosis.
Objectives: We hypothesized that FGF21 could exert anti-fibrotic properties in the lung.
Article Synopsis
- The study examines lung transplantation (LT) outcomes in patients aged 65 and older compared to younger recipients, emphasizing that age shouldn't be a strict barrier for the procedure.
- Researchers conducted a retrospective analysis of patients who underwent LT at Bichat Hospital, tracking 90-day mortality and other long-term health markers.
- Results showed that while elderly patients had better short-term lung function post-transplant, their overall survival rates and mortality within the first year were similar to those of younger patients.
Objective: Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.
Methods: Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry.