Publications by authors named "Y Caliskan"
Background: Recent studies suggest that approximately 10% of patients with chronic kidney disease (CKD) have disease-causing genetic variants, an observation relevant to evaluation of kidney transplant candidates.
Methods: We retrospectively investigated the diagnostic yield of genetic testing in kidney transplant candidates evaluated at our program (January 1, 2021-December 8, 2022). Inclusion criteria were as follows: first-degree relative(s) with CKD/end-stage kidney disease (ESKD), early-onset CKD, focal segmental glomerulosclerosis, cystic kidney disease, alternative complement pathway-associated diseases, or ESKD of unknown cause.
Article Synopsis
- Thoracic and abdominal aortic aneurysms have different genetic and clinical characteristics, which can be better understood using single-cell RNA sequencing rather than traditional bulk RNA methods that average gene expression across all cells.* -
- Analysis of single-cell datasets identified three distinct populations of smooth muscle cells (SMCs) in aortic tissues, with a significantly higher proportion of a unique SMC group in TAA compared to AAA.* -
- Certain genes linked to extracellular matrix organization and insulin-like growth factor transport were found to be upregulated in TAA SMCs, suggesting these may play a role in the development of TAAs; further studies are needed to explore these pathways.*
Background: Malignancy in pilonidal sinus disease (PSD) is rare, with squamous cell carcinoma (SCC) being the most common type. This study aims to assess the incidence of malignancy in PSD and identify risk factors to guide more targeted pathological examination strategies.
Methods: A retrospective analysis was conducted on 1505 patients who underwent surgical excision of PSD between January 1, 2014, and December 31, 2023.
Thromboembolic events and atrial fibrillation are common among kidney transplant recipients (KTRs), and these conditions typically require anticoagulation. Traditionally, vitamin K antagonists were used for management, but the use of direct oral anticoagulants (DOACs) has increased in KTRs. In the general population, DOACs are recommended over warfarin, but the applicability of these recommendations to KTRs is unclear because of risk-benefit concerns.
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