Cell free supernatants of Bifidobacterium adolescentis and Bifidobacterium longum suppress the tumor growth in colorectal cancer organoid model.

The probiotic gut microbiome and its metabolites are pivotal in regulating host metabolism, inflammation, and immunity. Host genetics, colonization at birth, the host lifestyle, and exposure to diseases and drugs determine microbial composition. Dysbiosis and disruption of homeostasis in the beneficial microbiome have been reported to be involved in the tumorigenesis and progression of colorectal cancer (CRC).

Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis.

Introduction: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, notably delta and omicron, has significantly accelerated the global pandemic, worsening conditions worldwide. However, there is a lack of research concerning the molecular mechanisms related to immune responses and metabolism induced by these variants.

Methods: Here, metabolomics combined with transcriptomics was performed to elucidate the immunometabolic changes in the lung of hamsters infected with delta and omicron variants.

Production of non-triple helical collagen polypeptides under Hypoxia and the Implication for Tumor.

Non-triple helical collagen polypetides (NTHs) are alternative gene products lacking the typical collagen triple-helical structure. This study investigated NTH production in tumor cells and tissues. NTH α1(IV) was detected in various human tumor cell lines and extracted from human lung cancer tissues and tumors in mice.

Exploring critical pathways using robust strategies: Nanodiamond electrocatalysts for promoting boron removal via electrosorption.

This study presents the first instance of a crucial route for the efficient removal of boron from effluents using a strategically applied electrosorption technology using nanodiamonds annealed under argon (denoted as A-NDs). We demonstrate a significant enhancement in adsorption capacity for boron removal facilitated by a flow-through electrosorption cell, and outline the results of surface characterization and electrochemical activity tests of the fabricated nanodiamond (ND) anodes (e.g.

Salvage pathway of vitamin B absorption in chickens with mutant tumor virus a receptor.

The tumor virus A receptor (TVA), a member of the low-density lipoprotein receptor (LDLR) family, serves as an entry receptor for Avian Leukosis Virus (ALV) subgroups A and K, as well as a receptor for vitamin B bound to transcobalamin. Naturally occurring genetic variants in the TVA gene determine susceptibility or resistance to ALV-A and -K, but the effects of these mutated TVA on vitamin B uptake have not been investigated systemically. We found four TVA variants comprising the wild type (TVA), a single nucleotide polymorphism variant (TVA), and two partial deletions in the splicing branch point region (TVA).