Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy.

Phytochemicals are typically natural bioactive compounds or metabolites produced by plants. Phytochemical-loaded nanocarrier systems, designed to overcome bioavailability limitations and enhance therapeutic effects, have garnered significant attention in recent years. The coronavirus disease 2019 (COVID-19) pandemic has intensified interest in the therapeutic application of phytochemicals to combat viral infections.

Validation of the advance care planning engagement survey in Singapore.

Background: Singapore has an ageing population. End-of-life care and advance care planning are becoming increasingly important. To assess advance care planning engagement, valid tools are required.

Temporal patterns in Malaysian rainforest soundscapes demonstrated using acoustic indices and deep embeddings trained on time-of-day estimationa).

Rapid urban development impacts the integrity of tropical ecosystems on broad spatiotemporal scales. However, sustained long-term monitoring poses significant challenges, particularly in tropical regions. In this context, ecoacoustics emerges as a promising approach to address this gap.

Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids.

Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no consensus exists on why ACSL1 is induced by inflammatory mediators in immune cells. We used a comprehensive and unbiased approach to investigate the role of ACSL1 induction by interferon type I (IFN-I) in myeloid cells in vitro and in a mouse model of IFN-I overproduction.

Use of the Consumer Health Literacy Quotient to Quantify and Explore Self-Care Readiness Among Consumers in Four Asia-Pacific Countries.

Background/objectives: Self-care has great potential to benefit consumers and health systems, but its mainstream adoption is hindered by a systemic lack of consumer health literacy (HL). Published data on consumer awareness of self-care and HL are limited for regions in Asia, and are needed to develop interventions to enhance HL and self-care for diverse populations in this region. The aim of this research was to describe and analyze patterns of HL and awareness of self-care among consumers in Asia.