Publications by authors named "Y C Loke"
Post-operative transesophageal echocardiography (TEE) is standard of care to evaluate for residual disease and quality of surgical repair. The residual lesion score (RLS) as defined by the pediatric heart network explored the impact of residual lesions on outcomes using discharge transthoracic echocardiogram (TTE). In tetralogy of fallot with pulmonary stenosis (TOF/PS), the residual right ventricular outflow tract (RVOT) gradient is one marker of quality of repair.
View Article and Find Full Text PDFArticle Synopsis
- - Cognitional heart disease is a major cause of infant mortality, and tissue-engineered vascular grafts present a promising approach for personalized treatment, but current design methods often lack individuality or require manual input.
- - This paper introduces a computational framework that automatically optimizes the shape of patient-specific vascular grafts using techniques like Bayesian optimization and a unique graft deformation algorithm, minimizing the need for human intervention.
- - Evaluation of the method using data from six patients demonstrated improved graft performance in terms of reduced pressure drop and wall shear stress, while also assessing how designs perform under steady versus transient conditions.
Background: Surveillance for heart transplant rejection by endomyocardial biopsy is invasive and may yield false negatives. T1 and T2 mapping from cardiac magnetic resonance can demonstrate elevations with rejection. We sought to evaluate longitudinal changes in T1 and T2 mapping in pediatric patients with heart transplant.
View Article and Find Full Text PDFIntroduction: Fast melt tablets (FMTs) provide a convenient dosage form that rapidly dissolves on the tongue without the need for water. Cocoa butter serves as a suitable matrix system for FMTs formulation, facilitating rapid disintegration at body temperature.
Objectives: This study aimed to formulate FMTs using cocoa butter as a base and investigate the effect of various disintegrants and superdisintegrants on their characteristics.
Geriatric patients have difficulty to comply to their medication regimen due to complicated medication administration schedule, dysphagia, reduced ability to swallow tablets and dementia. This is particularly more challenging among the Alzheimer Disease's patients. Therefore, a model drug, memantine hydrochloride has been formulated into an orally disintegrating film (ODF) for easier consumption.
View Article and Find Full Text PDF