Prioritizing protein targets for dyslipidaemia and cardiovascular diseases using Mendelian randomization in South Asians.

South Asians are at higher risk of dyslipidaemia-a modifiable risk factor for cardiovascular diseases (CVDs). We aimed to identify protein targets for dyslipidaemia and CVDs in this population. We used a two-sample Mendelian randomization (MR) approach, supplemented with MR-Egger, weighted median, colocalization, and generalized MR (GMR), to evaluate the effect of 2,800 plasma proteins on high/low/non-high-density lipoprotein cholesterol (HDL-C/LDL-C/nonHDL-C), total cholesterol, and triglycerides.

Enhancing virus-mediated genome editing for cultivated tomato through low temperature.

Viral vector-mediated gene editing is enhanced for cultivated tomato under low temperature conditions, enabling higher mutation rates, heritable, and virus-free gene editing for efficient breeding. The CRISPR/Cas system, a versatile gene-editing tool, has revolutionized plant breeding by enabling precise genetic modifications. The development of robust and efficient genome-editing tools for crops is crucial for their application in plant breeding.

A Narrative Review with Strategic Analysis of Home Care Services for Older Adults in Seoul, South Korea: Toward a Comprehensive Care Approach.

Purpose: This study aimed to establish a role framework and organizational redesign for home care services in response to the evolving internal and external environments in South Korea. The specific objectives were: (1) to perform a Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis based on the external and internal factors related to home care services; (2) to propose key ideas for restructuring services and human resources; and (3) to suggest strategies for enhancing the quality of home-based care services.

Patients And Methods: The policy landscape for older adult healthcare in Seoul, South Korea along with the current state and challenges of home care services were reviewed.

The crucial role of CEMIP in cancer metastasis: Mechanistic insights and clinical implications.

Cancer metastasis is the leading cause of cancer-related deaths, making early detection and the prevention of metastatic progression critical research priorities. Recent studies have expanded our understanding of CEMIP (KIAA1199, HYBID), revealing its involvement in cancer metastasis and its potential role in slowing cancer progression. CEMIP plays critical roles in several stages of cancer metastasis: First, CEMIP promotes cancer cell proliferation to maintain cell heterogeneity before the metastasis process.

Age and sex differences in the relationship of body weight changes with colon cancer risks: A nationwide cohort study.

Colon cancer is a significant health concern, and obesity is a well-established risk factor. However, previous studies have mainly focused on assessing body weight as a risk factor for colon cancer at a specific time point. This nationwide cohort study investigated the association between body weight changes, which can fluctuate throughout an individual's lifespan, and the incidence of colon cancer using the South Korean population database provided by the National Health Insurance Service (NHIS).