Publications by authors named "Y C Giam"
Rationale: The inflammasome is a key regulatory complex of the inflammatory response leading to interleukin-1β (IL-1β) release and activation. IL-1β amplifies inflammatory responses and induces mucus secretion and hyperconcentration in other diseases. The role of IL-1β in bronchiectasis has not been investigated.
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- Patients with bronchiectasis experience worse health outcomes due to infections, often linked to weakened neutrophil antimicrobial responses that allow bacteria to persist.
- The study investigated the effectiveness of gremubamab, a bispecific monoclonal antibody, in boosting the ability of neutrophils to kill bacteria associated with bronchiectasis.
- Results showed that gremubamab significantly improved neutrophil functions, including opsonophagocytic killing and phagocytosis, without interfering with the body's natural antibodies, thus reducing the harmful effects of the bacterial infection.*
Introduction: Sulforaphane can induce the transcription factor, Nrf2, promoting antioxidant and anti-inflammatory responses. In this study, hospitalised patients with community-acquired pneumonia (CAP) were treated with stabilised synthetic sulforaphane (SFX-01) to evaluate impact on clinical status and inflammation.
Methods: Double-blind, randomised, placebo-controlled trial of SFX-01 (300 mg oral capsule, once daily for 14 days) conducted in Dundee, UK, between November 2020 and May 2021.
Background: Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19), but the molecular changes contributing to altered neutrophil phenotypes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not fully understood. We used quantitative mass spectrometry-based proteomics to explore neutrophil phenotypes immediately following acute SARS-CoV-2 infection and during recovery.
Methods: Prospective observational study of hospitalised patients with PCR-confirmed SARS-CoV-2 infection (May to December 2020).