Publications by authors named "Y C Chiao"

With the development of the technology to generate transgenic and knockout mice in the 1990s, investigators had a powerful tool to directly test the impact of altering a specific gene on a biological process or disease. Over the past three decades, investigators have used transgenic and knockout mouse models, which have altered expression of antioxidant genes, to test the role of oxidative stress/damage in aging and age-related diseases. In this comprehensive review, we describe the studies using transgenic and knockout mouse models to test the role of oxidative stress/damage in aging (longevity) and three age-related diseases, e.

View Article and Find Full Text PDF
Article Synopsis
  • - The mTORC1 pathway plays a crucial role in aging by influencing cellular protein balance, and its hyperactivation is linked to aging and related diseases.
  • - Research using 4EBP1 knockout mice reveals that increased activity in the mTORC1/4EBP1 pathway leads to accelerated cardiac aging, with impaired heart function seen as early as middle age.
  • - Despite similar heart failure marker expressions in both 4EBP1 knockout and wild-type mice, the knockout mice show increased protein production and degradation, indicating a disruption in cellular protein homeostasis.
View Article and Find Full Text PDF

Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and the prevalence of CVDs increases markedly with age. Due to the high energetic demand, the heart is highly sensitive to mitochondrial dysfunction. The complexity of the cardiac mitochondrial proteome hinders the development of effective strategies that target mitochondrial dysfunction in CVDs.

View Article and Find Full Text PDF

Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases.

View Article and Find Full Text PDF

Oily wastewater threatens the environment and the human health. Membrane technology offers a simple and efficient alternative to separating oil and water. However, complex membrane modifications are usually employed to optimize the separation performance.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: