Publications by authors named "Y C Chia"
Background: Palbociclib plus an aromatase inhibitor is approved for treatment of patients with ER+/HER2- advanced breast cancer (ABC). In the PALOMA-4 trial, adding palbociclib to letrozole prolonged median progression-free survival in Asian women with ER+/HER2- ABC. Here, we report patient-reported outcomes (PROs) from PALOMA-4.
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- - The study examines how aging affects cognition and brain structure in older adults, focusing on individual differences and the impact of sociodemographic factors on cognitive decline.
- - Researchers analyzed a group of Southeast-Asian older adults through cognitive tests, brain imaging, and interviews to identify cognitive profiles and how they relate to brain health and socioeconomic status.
- - Findings revealed that specific cognitive impairments were linked to reductions in brain regions related to cognitive control and that lower socioeconomic standing and cognitive reserve contributed to poorer cognitive performance, highlighting the complex relationship between aging, brain health, and social factors.
Cardiovascular diseases (CVD) continue to be the leading cause of deaths and disability worldwide and the major contributor is hypertension. Despite all the improvements in detecting hypertension together with technological advances and affordable, efficacious and relatively free of adverse effects anti-hypertensive agents, we continue to struggle to prevent the onset of hypertension and to control blood pressure (BP) to acceptable targets. The poor control of hypertension is commonly due to non-adherence to medications.
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- Melioidosis is a serious tropical infection with limited understanding of how it affects the mediastinum, leading to a study that aimed to categorize its radiological features and assess patient demographics.
- A retrospective analysis of CT scans from 70 out of 486 melioidosis patients identified 41 with mediastinal involvement, revealing diverse morphological presentations including necrotic lymph nodes and fluid collections.
- Half of the patients had diabetes, and the study suggests that further research is needed to understand the implications of these findings and the prognosis of mediastinal melioidosis.