Network pharmacology: Changes the treatment mode of "one disease-one target" in cancer treatment.

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine (TCM) treatment of cancer. TCM is a new choice and hot spot in the field of cancer treatment. We have also previously published studies on TCM and network pharmacology.

Genomic profiles and their associations with microsatellite instability status, tumor mutational burden, and programmed death ligand 1 expression in Chinese patients with colorectal cancer.

Background: Colorectal cancer (CRC) is among the most prevalent malignancies globally, with a rising incidence observed in younger demographics. Despite surgical resection remaining the cornerstone of treatment, metastatic CRC poses significant therapeutic challenges. Immunotherapy, a mode of treatment that leverages the patient's immune system, presents a promising frontier in CRC management, particularly for late-stage cases with limited treatment options.

Small nucleolar RNA 42 facilitates the progression of hepatocellular carcinoma through PI3K/Akt signaling pathway.

Small nucleolar RNAs may serve as new potential biomarkers for the diagnosis and treatment of liver cancer. The purpose of our study was to reveal the mechanism small nucleolar RNA 42 (SNORA42) affects the proliferation and migration of liver cancer cells. Quantitative real-time PCR (qRT-PCR) was performed to detect the expression of SNORA42 and its host gene.

Misalignment tolerance enhancement of vector beams in a free-space optical communication link.

Optical misalignment between transmitter and receiver leads to power loss and mode crosstalk in a mode division multiplexing (MDM) free-space optical (FSO) link. We report both numerical simulations and experimental results on the propagation performance of two typical vector beams, C-point polarization full Poincaré beams (FPB), and V-point polarization cylindrical vector beams (CVB), compared to homogeneous polarization scalar vortex beams (SVB) under optical misalignment. The FSO communication performance under misalignment using different transmit beams is evaluated in terms of power loss, mode crosstalk, power penalty, etc.

640 Gbit/s FSO turbulence-resilient field trial utilizing the cylindrical vector beam.

Free-space optical (FSO) communication has the advantages of large bandwidth and high security and being license-free, making it the preferred solution for addressing the "last kilometer" of information transmission. However, it is susceptible to fluctuations in the received optical power (ROP) due to atmospheric turbulence and pointing errors, resulting in the inevitable free-space optical communication transmission performance degradation. In this work, we experimentally verified the turbulence resistance of the cylindrical vector beam (CVB) over a 3 km long free-space field trial link.