Publications by authors named "Y Bouattour"
Article Synopsis
- Pentobarbital sodium (PNa) can be used as an alternative to intravenous anesthesia for pediatric radiological procedures, but commercial suppositories are not available and must be compounded.
- This study developed fast-dissolving PNa suppositories using different formulations and tested their characteristics like softening time, dissolution rates, and resistance.
- Hydrophilic formulas showed superior performance for releasing PNa quickly compared to lipophilic ones, but further pharmacokinetic studies are needed to validate these findings.
Peripherally inserted central catheters (PICC-lines) used in neonatology are made of thermoplastic polyurethane (TPU) or silicone. These materials usually contain substances that may leach into drug vehicles or blood. In this extractables study, we determined the optimal extraction conditions using TPU films containing defined amounts of butylhydroxytoluene (BHT) and then applied them on unused and explanted PICC-lines.
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- Medical devices often use plasticized polyvinylchloride (PVC), but plasticizers can leach into solutions, posing a toxic risk to patients.
- The study aims to fluorinate PVC medical devices to create a barrier that limits plasticizer migration, and the process successfully formed C-F bonds without changing the devices' mechanical or optical properties.
- Testing showed that plasticizer migration from the fluorinated devices was significantly reduced and remained below detectable levels after 24 hours, with no cytotoxic effects observed on cells tested.
Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must be prepared by compounding pharmacies. In this study, two suppository formulations of 30, 40, 50, and 60 mg of pentobarbital sodium were developed using hard-fat Witepsol W25 either alone (formulation F1) or with oleic acid (formulation F2).
View Article and Find Full Text PDFStability studies are essential to be able to assign an expiration date to medications. Color variation is one of the organoleptic characteristics of actives substances or medications which can indicate the presence of contaminations, impurities or degradations products. However there is no data available comparing the often used visual examination with spectrophotometric measurements during stability studies.
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