Publications by authors named "Y Boettcher"
Article Synopsis
- * A large study involving over 150,000 individuals found that genetic effects on fasting insulin vary by sex, specifically at the IRS1 and ZNF12 gene locations, with women showing higher RNA expression levels for ZNF12.
- * The findings highlight that fasting insulin in women correlates more strongly with certain conditions like waist-to-hip ratio and anorexia nervosa, indicating that metabolic health differences between sexes may provide insight into their respective genetic influences.
A polymorphism in the promoter region of the human serotonin transporter (5-HTT)-coding SLC6A4 gene (5-HTTLPR) has been implicated in moderating susceptibility to stress-related psychopathology and to possess regulatory functions on human in vivo 5-HTT availability. However, data on a direct relation between 5-HTTLPR and in vivo 5-HTT availability have been inconsistent. Additional factors such as epigenetic modifications of 5-HTTLPR might contribute to this association.
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- A genome-wide association meta-analysis of body fat percentage (BF%) was conducted with data from 100,716 individuals to explore the genetic basis of adiposity and its connection to cardiometabolic diseases.
- Twelve genetic loci were identified as significantly associated with BF%, including eight known for overall adiposity and four novel loci.
- Findings indicate that some loci have a stronger effect on BF% compared to BMI, suggesting they are primarily linked to fat, while others influence both fat and lean mass, offering new insights into the relationship between body fat and disease risk.
Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- and type 2 diabetes-associated genetic variants located within or near genes that modulate brain activity and development. Among the top hits is rs17782313 near MC4R, encoding for the melanocortin-4-receptor, which is expressed in brain regions that regulate eating.
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