Publications by authors named "Y Bitterman"

Background: Condylar hyperplasia is a non-neoplastic overgrowth of the mandibular condyle. The disorder is progressive and causes gradual jaw deviation, facial asymmetry, and dental malocclusion. The only treatment capable of stopping hyperplastic growth is surgical condylectomy to remove the upper portion of the condyle containing the deranged growth center.

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Article Synopsis
  • - Tetralogy of Fallot is a congenital heart defect that can lead to long-term complications like progressive right ventricular (RV) failure due to issues like pulmonic regurgitation, even after surgical correction.
  • - The cellular causes of RV failure involve microvascular and mitochondrial problems, which often result in exercise intolerance that can be measured through cardiopulmonary exercise testing to help predict outcomes.
  • - Management of RV failure includes using diuretics to balance fluid levels and, in cases of severe heart failure, employing inotropes or mechanical support while monitoring any remaining heart issues that could affect treatment effectiveness.
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Background: The aim of this study was to investigate the relationship among right ventricular (RV) dilatation, dysfunction, and electromechanical dyssynchrony (EMD) in patients with repaired tetralogy of Fallot (rTOF).

Methods: Data from a prospective rTOF registry of subjects with moderate or greater pulmonary regurgitation (PR) and contemporary imaging were analyzed. Electrocardiograms and echocardiograms were analyzed for EMD (prolonged QRS duration [QRSd], echocardiographic septal flash, and mechanical delay) and mechanical dispersion.

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Acting to achieve goals depends on the ability to motivate specific behaviors based on their predicted consequences given an individual’s internal state. However, the underlying neuronal mechanisms that encode and maintain such specific motivational control of behavior are poorly understood. Here, we used Ca imaging and optogenetic manipulations in the basolateral amygdala of freely moving mice performing noncued, self-paced instrumental goal-directed actions to receive and consume rewards.

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