Publications by authors named "Y Binesh Lal"
Article Synopsis
- Klebsiella pneumoniae is a common pathogen in humans with high virulence and antimicrobial resistance, and this study explores its genetic variability across human, animal, and environmental sources.
- Research involved analyzing K. pneumoniae samples from clinical settings, livestock, and hospital sewage, highlighting significant genetic differences and the abundance of resistance and virulence genes.
- Findings suggest that the spread of highly resistant K. pneumoniae clones is primarily within human contexts, indicating that these strains likely evolved in hospitals rather than from animals or the environment, challenging current assumptions about AMR transmission.
An emerging pathotype of Klebsiella pneumoniae, initially identified in Southeast Asian countries, has now spread to multiple countries, including India. These convergent strains, carrying both resistance and virulence determinants, are classified as multidrug-resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp). Since the initial reports, there has been a concerning surge in infections caused by this pathotype globally.
View Article and Find Full Text PDFBackground: India is among the nations reporting substantial healthcare burden linked to pneumococcal infections. Nafithromycin is a novel lactone ketolide antibiotic, which recently entered Phase 3 development in India for the indication of community-acquired bacterial pneumonia (CABP).
Objectives: To assess the activity of nafithromycin against serotyped invasive and non-invasive isolates, collected from nine medical centres across India.
Objectives: Elizabethkingia spp. are Gram-negative, glucose-non-fermenting bacilli that are ubiquitous in natural environments such as soil, plant and water sources. Besides environmental sources, the bacterium can be found in hospital environments, particularly medical equipment and reagents.
View Article and Find Full Text PDFMurine typhus is an endemic infectious disease caused by Rickettsia typhi and is transmitted by fleas. It typically causes a mild illness with symptoms of fever, rash, headache, chills, and non-specific gastrointestinal complaints. However, there have been no reported cases in the literature of murine typhus infection causing symptoms of acute psychosis and disseminated intravascular coagulation (DIC).
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