Publications by authors named "Y Belenkov"
MiRNA-34a, miRNA-145, and miRNA-222 Expression, Matrix Metalloproteinases, TNF-α and VEGF in Patients with Different Phenotypes of Coronary Artery Disease.
Int J Mol Sci
December 2024
The development of different phenotypes of coronary artery (CA) lesions is regulated via many various factors, such as pro-inflammatory agents, zinc-dependent endopeptidases, growth factors and circulating microRNAs (miRs). To evaluate the expression levels of miR-34a, miR-145 and miR-222, tumor necrosis factor α (TNF-α), matrix metalloproteinases (MMP-1, -9, -13 and -14) and vascular endothelial growth factor (VEGF) in patients with different phenotypes of coronary artery disease (CAD): ischemia/angina with non-obstructive coronary arteries (INOCA/ANOCA) and obstructive CAD (oCAD) compared with a control group. This cross-sectional observational study included 157 subjects with a verified CAD diagnosis (51 patients with INOCA, 76 patients with oCAD and 30 healthy volunteers).
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- This study aimed to identify specific metabolomic and structural markers related to left ventricular (LV) remodeling in patients with chronic heart failure (CHF) caused by ischemia and a low ejection fraction (EF).
- The research involved comparing 56 CHF patients with 50 control patients, measuring various amino acids and acylcarnitines, alongside echocardiographic assessments over 6 months.
- Results showed that CHF patients had lower levels of certain amino acids and higher levels of acylcarnitines, with specific markers significantly influencing long-term LV remodeling outcomes.
Article Synopsis
- The study aimed to identify why patients with chronic heart failure (CHF) in Russia have a poor prognosis, using data from various population samples and medical records over several years.
- It established the prevalence of CHF in the Russian population, finding that 8.2% of individuals meet soft criteria for CHF, while 3.1% met strict criteria, with significant influences from conditions like hypertension and ischemic heart disease.
- The prognosis for these patients is grim, with over half dying within four years after acute decompensated heart failure (ADHF), and most patients with severe CHF not surviving beyond ten years, primarily due to inadequate medication use and poor patient follow-up.
Article Synopsis
- The CHANCE study investigated the effects of a monitoring and education program for patients with chronic heart failure, comparing an intervention group (IG) receiving structured support to a control group (CG) receiving standard care.
- Results showed that the IG had significantly lower mortality rates (8.3%) compared to the CG (13.0%), and a relative risk of 0.68 for death, indicating the program's effectiveness in saving lives.
- Additionally, the IG exhibited better improvements in clinical condition, functional capabilities (as seen in the 6-minute walk test), and overall quality of life, with significant reductions in anxiety and depressive symptoms over 12 months.
During the 25 years of the existence of the Russian Society of Experts in Heart Failure, it has become the most numerous and authoritative medical association. The Society has representative offices in 52 regions of Russia, and its active members amount to more than 4,000 various specialists. More than 200 Schools, regional conferences, and annual Congresses have been held annually.
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