Synthesis, pharmacological evaluation, and study of new 3-furan-1-thiophene-based chalcones as antibacterial and anticancer agents.

New 3-furan-1-thiophene-based chalcones were synthesized, characterized and pharmacologically evaluated as antibacterial and anticancer agents against two bacterial species; Gram-positive () and Gram-negative (). All tested final compounds were active against the two bacterial species; and . Especially compound AM4 showed large inhibition zone (27.

Enhanced intramolecular charge transfer and near-infrared fluorescence in 4-dimethylamino-chalcone analogues through extended conjugation: synthesis, photophysical properties, and theoretical modelling.

The distinctive characteristics of near-infrared fluorescent organic molecules render them indispensable across diverse applications, from energy harvesting to bioimaging and sensing technologies. In this work, we continue our investigation on the chalcone derivative, 4-dimethylamino-2'-hydroxychalcone (DHC, = 1; where is the number of olefinic bonds), by expanding the number of central double bonds ( = 2 (2DHC) and = 3 (3DHC)). Additionally, we also synthesized the structurally related chalcones lacking the OH group (DC, 2DC, 3DC) in order to obtain a comprehensive understanding of their effects on the intramolecular charge transfer (ICT).

Design, Synthesis, Antimicrobial Properties, and Molecular Docking of Novel Furan-Derived Chalcones and Their 3,5-Diaryl-∆-pyrazoline Derivatives.

The present work focuses on the synthesis and preliminary structure activity relationships (SARs) of furan-derived chalcones and their corresponding ∆-pyrazoline derivatives as antimicrobial agents. Eight novel chalcone derivatives and eight ∆-pyrazoline compounds were synthesized in moderate to good isolated yields. The target compounds were evaluated as antimicrobial agents against two Gram-positive ( and ), two Gram-negative ( and ), and fungi () species.

Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome.

Metabolic syndrome (MetS) has become an increasing global health problem, which leads to cardiovascular diseases and type 2 diabetes. extracts have been reported to possess several biological activities. In this study, an ethyl acetate extract prepared from seeds of the Iraqi Kurdistan region was analyzed to identify its chemical constituents.

Isolation and Identification of Phytocompounds from and Their Biological Potentials.

Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (), lupanyl myristoate () and lignanolactone ().