Publications by authors named "Y Baazia"
Article Synopsis
- New strains of RNA viruses, like HCV-1b, arise mainly from mutations and recombination; a specific mutation involving V3 duplications in the NS5A gene is linked to worse liver disease outcomes.
- The study used direct sequencing and quasispecies analysis on 27 mutant strains, finding distinct clusters of either mutant or wild-type strains that have persisted for at least a decade.
- Findings suggest that the V3 duplication resulted from rare non-homologous recombination over a century ago, highlighting how such genetic changes can impact viral disease severity.
Background: The NS5A protein of the hepatitis C virus has been shown to be involved in the development of hepatocellular carcinoma.
Objectives: In a French multicenter study, we investigated the clinical and epidemiological features of a new HCV genotype 1b strain bearing a wide insertion into the V3 domain.
Study Design: We studied NS5A gene sequences in 821 French patients infected with genotype 1b HCV.
The pretherapeutic presence of protease inhibitor (PI) resistance-associated variants (RAVs) has not been shown to be predictive of triple-therapy outcomes in treatment-naive patients. However, they may influence the outcome in patients with less effective pegylated interferon (pegIFN)-ribavirin (RBV) backbones. Using hepatitis C virus (HCV) population sequence analysis, we retrospectively investigated the prevalence of baseline nonstructural 3 (NS3) RAVs in a multicenter cohort of poor IFN-RBV responders (i.
View Article and Find Full Text PDFLiver steatosis is a main histopathological feature of Hepatitis C (HCV) infection because of genotype 3. Steatosis and/or mechanisms underlying steatogenesis can contribute to hepatocarcinogenesis. The aim of this retrospective study was to assess the impact of infection with HCV genotype 3 on hepatocellular carcinoma (HCC) occurrence in patients with ongoing HCV cirrhosis.
View Article and Find Full Text PDFArticle Synopsis
- * A study using Bayesian coalescent phylogenetics analyzed the E1 gene and NS3/4 genomic segments of genotype 5a isolates to determine the epidemic's origin and transmission history.
- * The findings suggest that HCV genotype 5a strains in France diverged around 1939, with familial and medical transmission routes playing significant roles in its spread, particularly in the central region.