Automatic machine learning accurately predicts the efficacy of immunotherapy for patients with inoperable advanced non-small cell lung cancer using a computed tomography-based radiomics model.

Purpose: Patients with advanced non-small cell lung cancer (NSCLC) have varying responses to immunotherapy, but there are no reliable, accepted biomarkers to accurately predict its therapeutic efficacy. The present study aimed to construct individualized models through automatic machine learning (autoML) to predict the efficacy of immunotherapy in patients with inoperable advanced NSCLC.

Methods: A total of 63 eligible participants were included and randomized into training and validation groups.

Correlations of the expression of Cx43, SCF, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues.

Background: Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination. Conversely, reduced expression results in a loss of this capacity to facilitate cyclin E degradation. The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein, with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues

Aim: To investigate the correlation between expression of Cx43, SKP1/Cullin1/F-box (SCF), p-cyclin E1 (ser73, thr77, thr395) and clinicopathological indexes in colon cancer.

Influence of dietary protein and fiber intake interactions on the human gut microbiota composition and function: a systematic review and network meta-analysis of randomized controlled trials.

Quantity and source of dietary protein intakes impact the gut microbiota differently. However, these effects have not been systematically studied. This review aimed to investigate these effects whilst controlling for fiber intake.

High-fidelity and adaptive forward-phase-based vibration sensing using a Wiener filter in DSCM systems under commercial ECLs.

In this Letter, we propose and experimentally validate a high-fidelity and adaptive forward-phase-based vibration sensing using a Wiener filter (WF). In commercial coherent digital subcarrier multiplexing (DSCM) systems under external cavity lasers (ECLs), frequency-domain pilot tones (FPTs) in subcarrier intervals are employed for dynamic frequency offset estimation (FOE), carrier phase estimation (CPE), and polarization demultiplexing. The phase estimated by the CPE module is processed with the WF to achieve high-fidelity extraction of the vibration-induced phase.

Low-complexity 24-h 29-km inter-island real-time FSO communication under strong turbulences.

Free space optical communication (FSOC) technology can be used for data transmission between ocean islands as backup wireless communication networks to cope with traffic surges and emergencies. In this paper, we experimentally demonstrate the results of a 24-h real-time single-wavelength 2.5-Gbps FSOC between two islands 29 km apart at a low altitude with low complexity.