Publications by authors named "Y B Matos"
Molecular docking and antibacterial and antibiotic-modifying activities of synthetic chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one in a MepA efflux pump-expressing Staphylococcus aureus strain.
Folia Microbiol (Praha)
November 2024
Article Synopsis
- Bacterial resistance, particularly in Staphylococcus aureus, poses a serious global public health challenge, driving researchers to explore new solutions such as efflux pump inhibitors.
- A newly synthesized chalcone was tested for its antibacterial properties, revealing it does not have direct antibacterial activity, but it can enhance the effectiveness of existing antibiotics like ciprofloxacin and ethidium bromide.
- Molecular docking simulations indicate that the chalcone likely functions as a MepA efflux pump inhibitor, targeting the same binding site as known inhibitors.
Effect of chloramine T and chlorhexidine in reducing gingivitis in patients admitted to a reference hospital for cardiopulmonary care: a randomized, controlled clinical trial.
Clin Oral Investig
October 2024
Article Synopsis
- The study evaluates Chloramine T as a treatment for gingivitis in hospitalized patients, comparing its effectiveness to Chlorhexidine and a placebo.
- After five and ten days, both chloramine T and chlorhexidine groups showed significant improvements in gingival health, while the control group showed no changes.
- Chloramine T proved to be as effective as chlorhexidine in reducing gingivitis without the negative side effects associated with long-term chlorhexidine use, suggesting its potential as a safer alternative for hospital patients.
Neuroinflammation is a key component underlying multiple neurological disorders, yet non-invasive and cost-effective assessment of in vivo neuroinflammatory processes in the central nervous system remains challenging. Diffusion weighted magnetic resonance spectroscopy (dMRS) has shown promise in addressing these challenges by measuring diffusivity properties of different neurometabolites, which can reflect cell-specific morphologies. Prior work has demonstrated dMRS utility in capturing microglial reactivity in the context of lipopolysaccharide (LPS) challenges and serious neurological disorders, detected as changes of microglial metabolite diffusivity properties.
View Article and Find Full Text PDFPurpose: Neurodevelopmental disorders, such as autism spectrum disorder (ASD), have been increasingly associated with eosinophilic gastrointestinal disorders (EGID). However, the relationship between these diseases remains unclear. We performed a systematic review with meta-analysis to address this issue.
View Article and Find Full Text PDFWe verified the possibility of cooling peccary semen for 4, 24, and 48 h before cryopreservation, using different dilution media (TRIS + egg yolk (20%) and PRIMXcell Ultra). Ten ejaculates were divided equally into six aliquots and then diluted. Two aliquots were stored in a biological incubator (4 h), and the remaining aliquots were stored in a commercial container, the Botutainer (24 and 48 h), both at 5 °C.
View Article and Find Full Text PDF