Publications by authors named "Y Ashikaga"
Nonspecific inflammatory pseudotumor of the maxillary and temporal fossa: a study of seven cases.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Objective: Inflammatory pseudotumor (IPT) is a rare, locally aggressive, benign neoplasm of unknown etiology. Because of its aggressive clinical behavior and locally destructive or infiltrative features, it may be mistaken for a malignant tumor. Approximately 5%-44% of extrapulmonary IPT occur in the head and neck, primarily affecting the orbit.
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- Photoimmunotherapy uses a targeted drug activated by infrared light to induce cell death in tumors, but accurately placing the necessary illumination devices for deep lesions is challenging during surgery.* -
- The development of "SlicerPIT," a planning software, allows for effective preoperative placement of illumination devices in 2D and 3D, improving guidance during actual procedures through integration with surgical navigation systems.* -
- In trials with three patients, SlicerPIT successfully guided the placement of treatment devices, yielding positive results with tumor necrosis and shrinkage, indicating its potential to enhance photoimmunotherapy outcomes.*
Article Synopsis
- Tongue squamous cell carcinoma (SCC) is associated with a high likelihood of cervical lymph node metastasis (CLNM), leading to a poor prognosis.
- A study of 89 patients focused on identifying clinicopathological features that predict CLNM in early-stage tongue SCC, using methods like Kaplan-Meier survival analysis and Cox regression.
- Significant risk factors for CLNM included clinical stage T2, depth of invasion greater than 5 mm, tumor budding, and high-grade differentiation, with about 25.8% of patients exhibiting CLNM, indicating the need for close monitoring in at-risk patients post-surgery.
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- The 8th edition of the cancer staging system incorporates depth of invasion (DOI) and extranodal extension (ENE) for assessing oral cavity cancer, enhancing its prognostic accuracy compared to the 7th edition.
- A review of 2,118 patients showed that the new system allowed for a significant number of cases to be upstaged, leading to better differentiation and understanding of the disease's progression.
- Overall, the updated staging system improved survival prediction and highlighted patients at higher risk of mortality, making it a more effective tool for clinicians.
Photochemical switching of cytotoxicity by using spiropyran compounds with pyridinium and alkyl groups was investigated. The spiropyran compound, , with a hexyl group as the alkyl group displayed negative photochromism, in which the hydrophilic open merocyanine form (MC form) was stable and isomerized to the hydrophobic closed spiro form (SP form) by visible light irradiation. Both MC and SP forms exhibited amphiphilicity because of the hydrophobic hexyl and hydrophilic pyridinium groups introduced.
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