Publications by authors named "Y Arudchelvan"
The aims of this study were to investigate if Toll-like receptor 4 (TLR4) is expressed in the medullary dorsal horn (MDH) and if medullary application of a TLR4 antagonist (lipopolysaccharides from , LPS-RS) can attenuate changes in nociceptive sensorimotor responses or TLR4 expression that might be evoked by mustard oil (MO) application to the right maxillary first molar tooth pulp. Of 41 adult male Sprague-Dawley rats used in the study, 23 received intrathecal application of the TLR4 antagonist LPS-RS (25 μg/10 μl; LPS-RS group) or isotonic saline (10 μl; vehicle control group) 10 min before pulpal application of MO (95%; 0.2 μl).
View Article and Find Full Text PDFEffects of two wattages of low-level laser therapy on orthodontic tooth movement.
Arch Oral Biol
August 2017
Introduction: Mixed outcomes have been found in animal and clinical studies with regard to the use of low-level laser therapy (LLLT) as a modality to accelerate orthodontic tooth movement (OTM). One major reason for the variable findings is the different methodologies and protocols for laser therapy use.
Objective: The aim of this study was to determine whether orthodontically moved molars exposed to two different wattages at the same energy density of LLLT exhibited differences in the amount of tooth movement and molecular and histological changes in the adjacent periodontal areas.
Article Synopsis
- Craniosynostosis is a birth defect caused by the early fusion of cranial sutures, leading to syndromes like Crouzon, Pfeiffer, and Apert, which show symptoms such as facial abnormalities and, in some cases, limb defects.
- Most known mutations in syndromic craniosynostosis involve the Fibroblast Growth Factor Receptor-2 (FGFR2), and recent studies suggest a link between these mutations and gastrointestinal tract disorders.
- Research indicated that patients with FGFR-associated craniosynostosis had higher instances of intestinal malrotation, and a mouse model with an FGFR2 mutation displayed similar gastrointestinal issues, highlighting the potential connection between FGFR mutations and developmental problems in both the skull
Expression studies have implicated FLRT2 in cranial neural crest cell migration and prechondrogenic cell condensation during craniofacial skeletogenesis. We aimed to determine whether FLRT2 was involved in mediating cell-matrix interactions in the ATDC5 chondroprogenitor cell line. Immunolocalization experiments of ATDC5 cells revealed that FLRT2 was present on the cell membrane as well as extracellularly, where it colocalized with Fibronectin (Fn).
View Article and Find Full Text PDFThe expression of PACAP receptor (PAC1-R) was investigated in the thymus of rats and rhesus monkeys. In the rat thymus, PAC1-R positive cells were found in the intermediate type of thymic epithelial cells of the medulla. PAC1-R-positive cells were also seen in the thymic medulla of the rhesus monkey.
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