Publications by authors named "Y Arimura"

Backgroud Aims: Regenerative therapies employing cell therapy products (CTPs) have attracted considerable attention. Biodistribution (BD) evaluation of CTPs is mainly performed to clarify the cell survival time, engraftment, and distribution site. This evaluation is crucial for predicting the efficacy and safety profiles of clinical studies based on non-clinical BD study outcomes.

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Nitric oxide (NO) has been reported to have a cytotoxic effect on various types of cancer. However, the efficient delivery of NO donors to tumors remains challenging. The present study used ibuprofen, which has a high binding affinity to human serum albumin (HSA).

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Article Synopsis
  • This study focused on understanding the clinical features and treatment outcomes of Japanese patients newly diagnosed with Takayasu arteritis (TAK) during the initial two years of their treatment.
  • A total of 129 patients were analyzed, with a majority being women, and common clinical symptoms related to large-vessel lesions, particularly in areas like the carotid and subclavian arteries.
  • The results highlighted that 82.9% of patients achieved clinical remission at 24 weeks, but only 39.5% maintained it at 52 weeks, with large-vessel symptoms linked to poorer outcomes for sustained remission.*
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Background/aim: Nitric oxide (NO) has various physiological activities. In this study, diclofenac (DF) which has a high affinity for human serum albumin (HSA) was nitrosylated to a novel NO donor (NDF). The cytotoxic effects and the mechanism of NDF were investigated.

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Introduction: The essential oil of Shikuwasa ( Hayata) primarily contains limonene and γ-terpinene, which have potential applications in stress management and relaxation. However, the psychological or physiological relaxation effects of Shikuwasa essential oil on humans are still unknown. This study aims to investigate the short-term relaxation effects of Shikuwasa essential oil, one of the less-studied varieties, compared to inhaling odour-free air in young female adults.

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