Impact of preceding treatment for head and neck squamous cell carcinoma on synchronous superficial esophageal squamous cell carcinoma.

Background: Patients with esophageal squamous cell carcinoma (ESCC) frequently develop synchronous head and neck squamous cell carcinoma (HNSCC). With advances in endoscopic technology and widespread screening of synchronous cancers, the detection of synchronous HNSCC and superficial ESCC (SESCC) is increasing. We aimed to evaluate the impact of preceding HNSCC treatment on synchronous SESCC.

Hyperdifferentiated murine melanoma cells promote adaptive anti-tumor immunity but activate the immune checkpoint system.

Accumulating evidence suggests that phenotype switching of cancer cells is essential for therapeutic resistance. However, the immunological characteristics of drug-induced phenotype-switching melanoma cells (PSMCs) are unknown. We investigated PSMC elimination by host immunity using hyperdifferentiated melanoma model cells derived from murine B16F10 melanoma cells.

Three Surgical Cases of Cecal Volvulus.

Cecal volvulus (CV) is a relatively rare disease; however, it often requires emergency surgery due to the low success rate of endoscopic treatment, in contrast to sigmoid volvulus. The mechanism of CV involves a mobile cecum at the base, triggered by factors such as constipation, high-fiber diets, laxative use, history of laparotomy or laparoscopic surgery, pregnancy, and prior colonoscopy, which twists the ileocecal region. Although CV is a benign disease, it can be fatal if treatment is delayed, so it is crucial to understand the pathophysiology and treatment.