IRE1α-XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs.

Hematopoietic stem cells must mitigate myriad stressors throughout their lifetime to ensure normal blood cell generation. Here, we uncover unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells (HSPCs) as a safeguard against myeloid leukemogenesis. Activated in part by an NADPH oxidase-2 mechanism, IRE1α-induced X-box binding protein-1 (XBP1) mediated repression of pro-leukemogenic programs exemplified by the Wnt-β-catenin pathway.

Chemical profile changes in Peanut seeds infected with aspergillus flavus via widely targeted metabolomics.

Peanut seeds are enriched with protein and fatty acids, making them susceptible to infection by Aspergillus flavus (A. flavus). The infected seeds are harmful to human health due to the aflatoxin contamination.

AIScholar: An OpenFaaS-enhanced cloud platform for intelligent medical data analytics.

This paper presents AIScholar, an intelligent research cloud platform developed based on artificial intelligence analysis methods and the OpenFaaS serverless framework, designed for intelligent analysis of clinical medical data with high scalability. AIScholar simplifies the complex analysis process by encapsulating a wide range of medical data analytics methods into a series of customizable cloud tools that emphasize ease of use and expandability, within OpenFaaS's serverless computing framework. As a multifaceted auxiliary tool in medical scientific exploration, AIScholar accelerates the deployment of computational resources, enabling clinicians and scientific personnel to derive new insights from clinical medical data with unprecedented efficiency.

-related gene C (MrgC) receptor activation induced inhibition of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia in a rat model of bone cancer pain.

Cancer pain is one of the most common symptoms in patients with advanced cancer. In this study, we aimed to investigate the effects of the -related gene C (MrgC) receptors on bone cancer pain. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured after the inoculation of Walker 256 mammary gland carcinoma cells into the tibia of adult Sprague-Dawley rats.