Effect of dalargin on apoptosis of l929 fibroblasts during cold stress.

Background: The search for compounds that can prevent cold stress-attributed apoptosis is of immediate interest. In this regard, the use of neuropeptides, in particular synthetic leu-enkephalin, as protectors is promising, due to their ability to prevent the development of apoptosis under some stresses.

Objective: To study apoptotic phenomena after cold stress and to evaluate the protective effect of dalargin on these processes.