Effectiveness of oral health educational program on the knowledge and practice of institutionalized orphan children in Alexandria, Egypt.

Aim: This study aimed to measure dental caries and to evaluate the improvement in the knowledge and practice of Orphan Children after implementing an educational program.

Materials And Methods: This study was an intervention pre-post design that included 80 children, aged 6-12 years. Intervention with an oral health education program was introduced to the orphans.

Exome sequencing in Nigerian children with early-onset epilepsy syndromes.

Objective: Nigeria, along with other Sub-Saharan African countries, bears the highest burden of epilepsy worldwide. This high prevalence is attributed to a combination of factors, including a significant incidence of infectious diseases, perinatal complications, and genetic etiologies. Genetic testing is rarely available and is not typically included in the routine diagnostic work-up for individuals with infantile and childhood epilepsy syndromes in these regions.

Performance of point-of-care glucose testing for the diagnosis of gestational diabetes in South Africa.

Objective: Lack of accessibility to oral glucose tolerance tests (OGTTs) in South Africa means many pregnant women go without testing for gestational diabetes mellitus (GDM). This study evaluated point-of-care (POC) glucometers against the laboratory-based glucose method in pregnant women.

Methods: This was a cross-sectional study on pregnant women attending the prenatal clinic in Johannesburg who were recommended for the OGTT.

DciA secures bidirectional replication initiation in Vibrio cholerae.

Replication is initiated bidirectionally in the three domains of life by the assembly of two replication forks at an origin of replication. This is made possible by the recruitment of two replicative helicases to a nucleoprotein platform built at the origin of replication with the initiator protein. The reason why replication is initiated bidirectionally has never been experimentally addressed due to the lack of a suitable biological system.