Publications by authors named "Y A Zorkina"

Numerous brain imaging studies have reported white matter alterations in schizophrenia, but the lipidome analysis of the corresponding tissue remains incomplete. In this study, we investigated the lipidome composition of six subcortical white matter regions corresponding to major axonal tracks in both control subjects and schizophrenia patients. All six regions exhibited a consistent pattern of quantitative lipidome alterations in schizophrenia, involving myelin-forming and mitochondria associated lipid classes.

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. Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. It has been suggested that the factors that cause pathologic changes and lead to the development of AD may also include changes in certain neuropeptides.

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Article Synopsis
  • - The study examines the potential role of lipids as biomarkers for diagnosing anxiety and depression, which are major contributors to mental health issues and disability, despite the lack of existing biochemical tests for these conditions.
  • - Researchers analyzed blood plasma lipid levels in a group of 604 urban individuals and compared them to 32 patients with clinical depression, finding significant correlations between lipid levels and the severity of depressive symptoms.
  • - The findings suggest that lipid alterations seen in clinically depressed patients can also be observed in the general population, leading to the creation of a predictive model with high accuracy for identifying individuals with severe depressive symptoms.
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Background: Post-traumatic stress disorder (PTSD) can occur after a traumatic event. PTSD is characterized by nightmares, flashbacks and avoidance of stressors. It currently affects 2-8% of the population, with military personnel particularly susceptible.

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Article Synopsis
  • Schizophrenia affects brain structure and function, with research focusing on both anatomical and molecular changes, particularly in lipids and metabolites.
  • A spatial analysis of lipid composition in specific neocortical regions (BA9 and BA22p) aims to understand how schizophrenia alters lipid profiles in gray and white matter.
  • Findings indicate that lipid changes are distributed unevenly, with more pronounced differences in the subcortical white matter of BA22p compared to BA9, revealing varying impacts on lipid classes between regions and tissue types.
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