Publications by authors named "Y A Osorio-Osorno"
Introduction: The substitution of reference drugs for similar, new or existing drugs in the market is a dilemma present in daily dental procedures. In order to decide whether or not to adopt a new drug in relation to the reference, a clinical trial can provide the necessary evidence.
Methods: A total of 179 healthy volunteers (18-25 years) requiring extraction of mandibular third molars completed the study.
Background: Liquid-based cytology (LBC) has improved exfoliative cytology by facilitating the extraction of more precise information from epithelial cells. The aim of this study was to optimize a protocol using a conventional cytobrush to perform LBC, obtaining oral keratinocytes for their further cellular and molecular analysis.
Methods: LBC was performed in 30 healthy donors from buccal mucosa.
Article Synopsis
- Oral lichen planus (OLP) is a chronic inflammatory disease linked to immune responses and potential malignant transformation, though its exact causes are still unclear.
- The review focuses on the role of Toll-like receptors (TLRs) in OLP, highlighting how TLR activation affects oral keratinocyte behavior, with a particular emphasis on the Interferon Regulatory Factor (IRF) family, especially IRF6.
- A hypothetical model suggests that TLR2 activation could regulate the inflammatory processes in OLP, emphasizing the need for further research on the molecular interactions involving oral keratinocytes.