Multi-Label Zero-Shot Learning Via Contrastive Label-Based Attention.

Multi-label zero-shot learning (ML-ZSL) strives to recognize all objects in an image, regardless of whether they are present in the training data. Recent methods incorporate an attention mechanism to locate labels in the image and generate class-specific semantic information. However, the attention mechanism built on visual features treats label embeddings equally in the prediction score, leading to severe semantic ambiguity.

ESAT-6 protein suppresses allograft rejection by inducing CD4Foxp3 regulatory T cells through IκBα/cRel pathway.

Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.

Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis and .

Object: Neuroinflammation mediated by microglia has emerged as a critical factor in ischemic stroke and neuronal damage. Gualou Guizhi Granule (GLGZG) has been shown to suppress inflammation in lipopolysaccharide (LPS)-activated microglia, though the underlying mechanisms and its protective effects against neuronal apoptosis remain unclear. This study aims to investigate how GLGZG regulates the Notch signaling pathway in microglia to reduce neuroinflammation and protect neurons from apoptosis.

Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children's motor performance in activities of daily living.

Background: The DCDDaily-questionnaire (DCDDaliy-Q) evaluates children's performance and participation in motor-based activities of daily living (ADLs), meeting diagnostic criterion B for developmental coordination disorder (DCD). Currently, there are no Chinese translations or growth references available. Thus, this study aimed to culturally adapt, validate, and establish reference norms for the DCDDaily-Q in Chinese children.

Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates.

Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.

Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.