Endothelin-1 and Nitric Oxide Levels in Exudative Age-Related Macular Degeneration.

Purpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD).

Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls.

Results: Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.