Effect of the modified NUTRIC score in predicting the prognosis of patients admitted to intensive care units.

Background: Nutritional deficiency is common in critically ill hospitalized patients. This condition may be aggravated by increased dietary requirements and deficiencies in nutrient absorption. This study aimed to evaluate the associations between the modified Nutritional Risk in Critically ill (mNUTRIC) score and mortality and morbidity in patients with sepsis.

In Vitro Comparison of Surface Characteristics and Bacterial Adhesion in Composite Resin-Based Materials for Additive, Subtractive, and Conventional Manufacturing.

Purpose: This study aims to compare the surface roughness (SR), contact angle (CA), surface free energy (SFE), and bacterial adhesion of resin-based materials used in additive, subtractive, and conventional manufacturing techniques.

Materials And Methods: This study involved four groups of 23 specimens: Indirect conventional resin composite (ICRC), subtractively manufactured resin composite (SMRC), additively manufactured resin composite (AMRC), and soda-lime-silica glass (SLSG). One specimen per group was analyzed by Energy Dispersive X-ray Spectroscopy (EDS) before polishing.

Protocol to study electrophysiological properties of hPSC-derived 3D cardiac organoids using MEA and sharp electrode techniques.

Continuing advancements in human pluripotent stem cell (hPSC)-derived complex three-dimensional (3D) cardiac tissues require the development of novel technologies or adaptation of existing technologies to understand the physiology of the derived 3D cardiac tissues. In this protocol, we describe the use of multielectrode array (MEA) and sharp electrode electrophysiology techniques to investigate the electrical properties of 3D cardiac organoids. This protocol deciphers the electrical behavior of 3D cardiac organoids at both the single-cell level and tissue level.

Investigation of the relationship between screen usage habits, behavioral problems and self-regulation skills of children aged 4-6.

Purpose: Amidst the multifaceted changes taking place in our dynamic world, the study of screen usage habits and their impacts on children has emerged as a burgeoning area of research interest. The current research endeavors to investigate and establish the correlation that exists between screen usage patterns, behavioral challenges, and self-regulation capabilities within the demographic of children aged 4-6 years.

Design And Methods: In the study, descriptive cross-sectional and relationship-seeking research model.

Ethical sensitivity and compassion competence in nursing students: Two-center study/comparison of two different cultures.

Background: Although the literature includes studies on nursing students' ethical sensitivity and compassion competence, no study has examined and compared these skills among nursing students from different cultures.

Aim: This research determined and compared the ethical sensitivity and compassion competency levels of nursing students in two different geographies, one in Turkey (Group I) and one in the Turkish Republic of Northern Cyprus (Group II), which hosts students with different cultural characteristics.

Design: Quantitative and cross-sectional research.

Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish.

In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate therapeutic efficacy in clinical trials. The FDA Modernization Act 2.0 heralds a transformative approach, advocating for the integration of alternative methods to conventional animal testing, including cell-based assays that employ human induced pluripotent stem cell (iPSC)-derived organoids, and organ-on-a-chip technologies, in conjunction with sophisticated artificial intelligence (AI) methodologies.

Clinical trials in-a-dish for cardiovascular medicine.

Cardiovascular diseases persist as a global health challenge that requires methodological innovation for effective drug development. Conventional pipelines relying on animal models suffer from high failure rates due to significant interspecies variation between humans and animal models. In response, the recently enacted Food and Drug Administration Modernization Act 2.

The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review.

Purpose Of Review: One of the important markers affecting aging processes is the increase in inflammatory markers. Many chronic diseases are associated with inflammation and chronic inflammation increases with aging. Inflammation can change with dietary components.

Reorganization of brain connectivity across the spectrum of clinical cognitive decline.

Clinical cognitive decline, leading to Alzheimer's Disease Dementia (ADD), has long been interpreted as a disconnection syndrome, hindering the information flow capacity of the brain, hence leading to the well-known symptoms of ADD. The structural and functional brain connectome analyses play a central role in studies of brain from this perspective. However, most current research implicitly assumes that the changes accompanying the progression of cognitive decline are monotonous in time, whether measured across the entire brain or in fixed cortical regions.

STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells.

Background/aim: Glioblastoma is one of the most aggressive tumours, resistant to all applied therapy regiments and prone to relapse. Median survival rates are therefore only expressed as months. STING agonists are immunomodulatory molecules that activate type I interferon expression, making them potentially useful in regulating the tumour microenvironment.

Siamese Graph Convolutional Network quantifies increasing structure-function discrepancy over the cognitive decline continuum.

Background And Objective: Alzheimer's disease dementia (ADD) is well known to induce alterations in both structural and functional brain connectivity. However, reported changes in connectivity are mostly limited to global/local network features, which have poor specificity for diagnostic purposes. Following recent advances in machine learning, deep neural networks, particularly Graph Neural Network (GNN) based approaches, have found applications in brain research as well.

Association of problems, coping styles, and preferred online activity with depression, anxiety, and other psychological disorders in Turkish adolescents diagnosed with chronic kidney disease.

Background: To assess depression, anxiety, and other psychological disorders in adolescents with chronic kidney disease (CKD) and determine the significant factors and the effect of digital media use on its scores among these patient groups.

Methods: The study was conducted as a cross-sectional study and included 84 adolescents with CKD and 68 healthy controls. The participants completed the Revised Child Anxiety and Depression Scale (RCADS).

The relationship between satisfaction with life, dietary attitude, and comfort level in hemodialysis patients: Analysis with machine learning approach.

Introduction: Hemodialysis (HD) patients have become a serious public health problem, the number of which is increasing every year worldwide. This study aimed to determine the relationship between satisfaction with life, dietary attitude, and comfort level in patients receiving HD treatment.

Methods: This research was conducted in a relational cross-sectional descriptive design.

Interventions to improve ethical decision-making skills in nursing students: A systematic review.

Background: Interventions to improve ethical decision-making are available in nursing education. Evidence of its effectiveness is essential.

Objective: This review examined the effectiveness of interventions to improve nursing students' ethical decision-making skills.

Comprehensive evaluation of patients with primary hyperoxaluria type 1: A nationwide study.

Background: Primary hyperoxaluria type 1 (PH1) is characterized by increased endogenous oxalate production and deposition as calcium oxalate crystals. The main manifestations are nephrocalcinosis/nephrolithiasis, causing impaired kidney function. We aimed to evaluate the clinical characteristics and overall outcomes of paediatric PH1 patients in Turkey.

Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours.

Background: PTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be attributed to PTEN loss, because of its role in establishing the tumour microenvironment. Therefore, this study aimed to represent the link between PTEN and cGAS-STING activity, a key mediator of inflammation, in tumour samples of glioblastoma patients.

Development and characterization of sustainable active pectin films: The role of choline chloride/glycerol-based natural deep eutectic solvent and lavender extracts.

This study aimed to evaluate the potential effects of choline chloride: glycerol-based natural deep eutectic solvent (NADES) as a plasticizer, NADES extract (NADESext) of lavender as both plasticizer and active ingredient, as well as the lyophilized extract (LE) of lavender at different concentrations (0.5 %, 1 %, and 2 %) on the physical, mechanical, optical, thermal, barrier, morphological, and antioxidant properties of pectin films. The properties of the films were compared to those of the neat pectin film and the film plasticized with glycerol.

Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action.

(BCTIV) is a yield-limiting geminivirus belonging to the genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles , whereas the virion strand organization is similar to the genus. Geminiviruses are known to avoid the plant defense system by suppressing the RNA interference mechanisms both at the transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS) levels.

Shrinkage of olfactory amygdala connotes cognitive impairment in patients with Parkinson's disease.

Unlabelled: During the caudo-rostral progression of Lewy pathology, the amygdala is involved relatively early in Parkinson's disease (PD). However, lesser is known about the volumetric differences at the amygdala subdivisions, although the evidence mainly implicates the olfactory amygdala. We aimed to investigate the volumetric differences between the amygdala's nuclear and sectoral subdivisions in the PD cognitive impairment continuum compared to healthy controls (HC).

The Mediating Role of Early Maladaptive Schemas in the Relationship between Temperament and Depressive Symptoms.

Objectives: Personality traits and early maladaptive schemas (EMSs) play an active role in the emergence, maintenance, and treatment of depressive mood. Studies draw attention to the close relationship between temperament and character traits, EMSs, and depression. The first aim of this study is to examine the relationships between temperament, character traits, and EMSs.

The effect of education on self-care agency and rational drug use of patients with COPD.

Objective: This study examined the effects of education given to patients diagnosed with the COPD on self-care agency and rational drug use.

Methods: This study has a pretest-posttest quasi-experimental design. Participants were divided into two groups, those who received training with the COPD Guide booklet (n = 40) and routine clinical care (n = 43).

Altered learning and transfer abilities in Korsakoff's syndrome depending on task complexity.

Korsakoff's syndrome (KS) is characterized by episodic memory impairment due to damage to the medial diencephalic structures. Although commonly associated with chronic alcoholism, starvation due to the hunger strike is one of its nonalcoholic causes. Learning the stimulus-response associations and transferring the just-learned associations to novel combinations were previously tested by specific tasks in memory-impaired patients with hippocampal, basal forebrain, and basal ganglia damage.

Wound healing activity of ethanolic extract in streptozocin-induced diabetic rats.

The aim of this study was to examine the in vivo wound healing potential of Hedge (endemic to Turkey) on excision and incision wound models in diabetic rats. Male Wistar albino rats, 3-4 months old and weighing 180-240g were used. The animals were randomly divided into five groups including Control, Vehicle and Fito reference, and two different concentrations (0.