Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2022
Objective: To investigate the effects of ferrostatin-1 (Fer-1) on cardiomyocyte hypoxia/reoxygenation injury and its mechanisms.
Methods: The original generation of myocardial cells were extracted from 1~3 d newborn SD rats, which were randomly divided into normal control group (control), hypoxia reoxygenation (H/R) group and hypoxia reoxygenation + iron death inhibitors group (H/R + Fer-1). After 52 h of culture, cells in H/R group were added with 4 mmol/L NaSO solution.