Publications by authors named "Xyryl Pablo"
Rv2477c is an antibiotic-sensitive manganese-dependent ABC-F ATPase in Mycobacterium tuberculosis.
Biochem Biophys Res Commun
January 2018
Article Synopsis
- Rv2477c is an ATP-binding cassette (ABC) protein in Mycobacterium tuberculosis that doesn't have transmembrane domains and is involved in various cellular processes.
- It shows strong ATPase activity, especially when manganese is present, and can also hydrolyze GTP, TTP, and CTP, but less efficiently.
- Mutations in key amino acids significantly reduce its ATPase activity, and antibiotics like tetracycline and erythromycin can inhibit this activity, suggesting Rv2477c may play a role in protein translation and antibiotic resistance.