Publications by authors named "Xvfeng Zhang"
Article Synopsis
- - The study investigates the role of DNA methylation in systemic lupus erythematosus (SLE), an autoimmune disease, to better understand its mechanisms and identify potential biomarkers and treatment targets.
- - Researchers analyzed DNA methylation patterns using advanced sequencing techniques in 4 SLE patients and 4 healthy individuals, discovering 702 differentially methylated regions (DMRs) related to SLE.
- - Key genes linked to SLE, particularly LCK and PTK2B, showed reduced mRNA expression in patients, indicating their potential as biomarkers for predicting SLE and guiding future therapeutic approaches.
Purpose: Sjögren's syndrome (SS) is a systemic autoimmune disease mainly characterized by dysfunction of exocrine glands. Studies on diagnosis models specific for SS patients are very limited. We aimed to use gene expression datasets from salivary glands to identify aberrant differentially expressed genes (DEGs) and pathways by bioinformatics and validate candidate genes by clinical minor labial gland biopsy (MSGB) samples, and finally build a combined gene quantitative diagnosis model of SS.
View Article and Find Full Text PDFObjective: Accurate and noninvasive pathologic grading of glioma patients before surgery was crucial to guiding clinicians to select appropriate treatment and improve patient prognosis. This study was performed to investigate the potential diagnostic value of diffusion kurtosis imaging (DKI) to distinguish high-grade gliomas (HGGs) from low-grade gliomas (LGGs) based on an evidence-based approach.
Methods: Relevant articles that used DKI to distinguish HGG from LGG in Embase, PubMed, China Knowledge Resource Integrated database (CNKI), Web of Knowledge, and Cochrane Libraries databases were electronically searched to April 31, 2018 by 2 reviewers.