Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches.

Hesperetin is one of the prominent flavonoids found in citrus fruit. Several research studies have reported that hesperetin can promote vasodilation in vascular tissue by increasing the level of nitric oxide and cyclic nucleotides. However, these may not be the only pathway for hesperetin to exert its vasodilatory effect.

Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice.

Background: Fibroblast growth factor 21 (), primarily secreted by the pancreas, liver, and adipose tissues, plays a pivotal role in regulating glucose and lipid metabolism. Acute pancreatitis (AP) is a common inflammatory disease with specific clinical manifestations. Many patients with diabetes present with concurrent inflammatory symptoms.

FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway.

Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and morbidity. Autophagy and Sirtuin type 1 (SIRT1) have been shown protective effects in response to liver injury. Previous studies have showed that Fibroblast growth factor 21 (FGF21) could alleviate acute liver injury (ALI), but the mechanism remains unclear.

Novel Surrogates for Membrane Fouling and the Application of Support Vector Machine in Analyzing Fouling Mechanism.

It is difficult to recognize specific fouling mechanisms due to the complexity of practical feed water, thus the current studies usually employ foulant surrogates to carry out research, such as alginate and xanthan gum. However, the representativeness of these surrogates is questionable. In this work, the classical surrogates (i.

Nitazoxanide induced myocardial injury in zebrafish embryos by activating oxidative stress response.

Nitazoxanide (NTZ) is a broad-spectrum antiparasitic and antiviral drug (thiazole). However, although NTZ has been extensively used, there are no reports concerning its toxicology in vertebrates. This study used the zebrafish as a vertebrate model to evaluate the safety of NTZ and to analyse the related molecular mechanisms.

A Global Overview of SARS-CoV-2 in Wastewater: Detection, Treatment, and Prevention.

A novel coronavirus (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) has attracted global attention due to its highly infectious and pathogenic properties. Most of current studies focus on aerosols released from infected individuals, but the presence of SARS-CoV-2 in wastewater also should be examined. In this review, we used bibliometrics to statistically evaluate the importance of water-related issues in the context of COVID-19.

Cinobufagin suppresses colorectal cancer growth via STAT3 pathway inhibition.

Colorectal cancer (CRC) has become one of the most common types of cancer with the highest morbidity and mortality rates globally. Cinobufagin, a natural product extracted from toad venom and a major active ingredient in cinobufotalin, exhibits high antitumor activity. Here, we investigated the and antitumor activities of cinobufagin and explored the underlying mechanisms in CRC.

Disruption of FGF Signaling Ameliorates Inflammatory Response in Hepatic Stellate Cells.

It is a well-documented event that fibroblast growth factors (FGFs) regulate liver development and homeostasis in autocrine, paracrine, and endocrine manners via binding and activating FGF receptors (FGFRs) tyrosine kinase in hepatocytes. Recent research reveals that hepatic stellate cells (HSCs) play a fundamental role in liver immunology. However, how FGF signaling in HSCs regulates liver inflammation remains unclear.

Synergetic effect between adsorption and photodegradation on rGO/TiO/ACF composites for dynamic toluene gaseous removal.

The toluene poses a serious threat to the atmospheric environment and human health. Herein, the reduced graphene oxide (rGO)/TiO immobilized on the activated carbon fiber (ACF) are fabricated by ultrasonic assisted sol-gel impregnation method to photodegrade dynamic toluene. Characterizations of rGO/TiO/ACF composites reveal that the majority of graphene oxide (GO) is reduced to rGO and rGO/TiO is evenly loaded onto the ACF surface in the form of a smooth film.