Analysis of Risk Factors for Restenosis after Interventional Treatment of Tuberculous Airway Stenosis.

Objective: Analysis of risk factors for restenosis after intervention for tuberculous airway stenosis.

Methods: We retrospectively collected the clinical data of patients diagnosed with tuberculous airway stenosis in the Second Hospital of Lanzhou University and Lanzhou Pulmonary Hospital from January 2021 to June 2023. The patients were divided into the restenosis group and the non-restenosis group according to whether or not restenosis occurred in the airway within 1 year after the intervention, and the differences in the clinical data between the two groups were compared, and the variables with statistically significant differences in the univariate analysis were analyzed by multifactorial binary logistic regression.

Composition-Tunable Bandgap Engineering of Horizontally Guided CdSSe Nanowalls for High-Performance Photodetectors.

Composition-adjustable semiconductor nanomaterials have garnered significant attention due to their controllable bandgaps and electronic structures, providing alternative opportunities to regulate photoelectric properties and develop the corresponding multifunction optoelectronic devices. Nevertheless, the large-scale integration of semiconductor nanomaterials into practical devices remains challenging. Here, we report a synthesis strategy for the well-aligned horizontal CdSSe ( = 0-1) nanowall arrays, which are guided grown on an annealed M-plane sapphire using chemical vapor deposition (CVD) approaches.

Effects of thermal pretreatment on the anaerobic digestion characteristics of fruit waste liquids.

Fruit waste is one of the main components of municipal waste. To study its potential and characteristics in anaerobic digestion, this study took fruit waste and its waste liquid as raw materials, investigate the influence of thermal pretreatment on the anaerobic digestion characteristics under 35 ± 17 °C. The anaerobic digestion materials were fruit waste liquid (group A1), fruit waste liquid after thermal pretreatment (group A2), fruit slurry (group A3), and the material of A2 and A3 mixed with municipal sludge (groups A4 and A5) has also been involved.

The effect of community environment on the trajectory of depressive symptoms and cohort differences among middle-aged and older Chinese adults.

Background: Urbanization has changed the living environment of middle-aged and older Chinese adults, but it also brings certain mental pressure to them. Few studies have explored the effect of community environment on the development trajectory and the cohort differences of depressive symptoms in Chinese individuals.

Methods: Based on the longitudinal data of the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020, using three-level hierarchical linear growth model, this study examined the effect of community environment on the trajectory of depressive symptoms and cohort differences among middle-aged and older Chinese adults in five cohorts from 1920 to 1929, 1930-1939, 1940-1949, 1950-1959, and 1960-1966.

The mechanism of quercetin in treating intracerebral hemorrhage was investigated by network pharmacology and molecular docking.

Background: The aim of this study was to explore the molecular mechanism of quercetin in the treatment of intracerebral hemorrhage.

Methods: Quercetin target genes and intracerebral hemorrhage target genes were collected from 5 databases. After standardized conversion of the obtained target genes through uniprot database, cross genes of the 2 were obtained using Venny 2.

Mechanics-informed autoencoder enables automated detection and localization of unforeseen structural damage.

Structural health monitoring ensures the safety and longevity of structures like buildings and bridges. As the volume and scale of structures and the impact of their failure continue to grow, there is a dire need for SHM techniques that are scalable, inexpensive, can operate passively without human intervention, and are customized for each mechanical structure without the need for complex baseline models. We present a novel "deploy-and-forget" approach for automated detection and localization of damage in structures.

Visible-Light-Induced Diselenide-Crosslinked Polymeric Micelles for ROS-Triggered Drug Delivery.

To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed and prepared for ROS-triggered on-demand doxorubicin (DOX) release. A rationally designed amphiphilic block copolymer, poly(ethylene glycol)--poly(diselenolane diol-co-isophorone diisocyanate)--poly(ethylene glycol) (PEG--PUSe--PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through the polycondensation reaction. In aqueous media, this type of amphiphilic block copolymer can self-assemble into micellar aggregates and encapsulate DOX within the micellar core, forming DOX-loaded micelles that are subsequently in situ core-crosslinked by diselenides via a visible-light-triggered metathesis reaction of Se-Se bonds.

Rational Fabrication of Nickel Vanadium Sulfide Encapsulated on Graphene as an Advanced Electrode for High-Performance Supercapacitors.

Supercapacitors (SCs) are widely recognized as competitive power sources for energy storage. The hierarchical structure of nickel vanadium sulfide nanoparticles encapsulated on graphene nanosheets (NVS/G) was fabricated using a cost-effective and scalable solvothermal process. The reaction contents of the composites were explored and optimized.

Four new guaiane sesquiterpenes from Agarwood of Aquilaria sinensis and their biological activity toward renal fibrosis.

Four undescribed guaiane sesquiterpenes, aquisinenoids I-L (2-5) and five known compounds were isolated from the resins of Aquilaria sinensis. Their structures were deduced based on spectroscopic data analysis, X-ray crystallography and ECD calculations. Biologically, compounds 1, 5, 6 and 9 showed anti-renal fibrosis activity, significantly reducing the levels of fibronectin, collagen I, and α-SMA.

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer.

Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive to chemo- and radiotherapies, and the effectiveness of immunotherapies remains unknown. Thus, a comprehensive analysis of the tumor microenvironment would facilitate effective therapies and provide evidence on CGRP's function outside the nervous system.

An Improved U-Net Infrared Small Target Detection Algorithm Based on Multi-Scale Feature Decomposition and Fusion and Attention Mechanism.

Infrared small target detection technology plays a crucial role in various fields such as military reconnaissance, power patrol, medical diagnosis, and security. The advancement of deep learning has led to the success of convolutional neural networks in target segmentation. However, due to challenges like small target scales, weak signals, and strong background interference in infrared images, convolutional neural networks often face issues like leakage and misdetection in small target segmentation tasks.

Dynamically Encircling Exceptional Points in Different Riemann Sheets for Orbital Angular Momentum Topological Charge Conversion.

Orbital angular momentum (OAM) provides an additional degree of freedom for optical communication systems, and manipulating on-chip OAM is important in integrated photonics. However, there is no effective method to realize OAM topological charge conversion on chip. In this Letter, we propose a way to convert OAM by encircling two groups of exceptional points in different Riemann sheets.

On-Wire Design of Axial Periodic Halide Perovskite Superlattices for High-Performance Photodetection.

Precise synthesis of all-inorganic lead halide perovskite nanowire heterostructures and superlattices with designable modulation of chemical compositions is essential for tailoring their optoelectronic properties. Nevertheless, controllable synthesis of perovskite nanostructure heterostructures remains challenging and underexplored to date. Here, we report a rational strategy for wafer-scale synthesis of one-dimensional periodic CsPbCl/CsPbI superlattices.

ApoE ε4-dependent alteration of CXCR3 CD127 CD4 T cells is associated with elevated plasma neurofilament light chain in Alzheimer's disease.

Unlabelled: Recent findings indicate a correlation between the peripheral adaptive immune system and neuroinflammation in Alzheimer's disease (AD). To characterize the composition of adaptive immune cells in the peripheral blood of AD patients, we utilized single-cell mass cytometry (CyTOF) to profile peripheral blood mononuclear cells (PBMCs). Concurrently, we assessed the concentration of proteins associated with AD and neuroinflammation in the plasma of the same subjects.

The impact of preoperative calcitonin screening on the prognosis of patients with medullary thyroid cancer: a retrospective multicenter cohort study.

Purpose: There is still controversy in different guidelines regarding the necessity of routine preoperative calcitonin (Ctn) testing in medullary thyroid cancer (MTC). The level of preoperative Ctn may influence the extent of surgery.

Methods: This retrospective multicenter cohort study involved 149 MTC patients from 6 centers between 2013 to 2023.

Microstructure and Hardness Characteristics of Swing-Arc SAW Hardfacing Layers.

Hot-rolled backup rolls are widely used in steel rolling and usually need to be repaired by arc hardfacing after becoming worn. However, a corrugated-groove defect commonly occurs on the roll surface due to the uneven hardness distribution in the hardfacing layers, affecting the proper usage of the roll. Accordingly, a new swing-arc submerged arc welding (SA-SAW) process is proposed to attempt to solve this drawback.

Prevalence of Mild Cognitive Impairment and Alzheimer's Disease Identified in Veterans in the United States.

Background: Diagnostic codes can be instrumental for case identification in Alzheimer's disease (AD) research; however, this method has known limitations and cannot distinguish between disease stages. Clinical notes may offer more detailed information including AD severity and can complement diagnostic codes for case identification.

Objective: To estimate prevalence of mild cognitive impairment (MCI) and AD using diagnostics codes and clinical notes available in the electronic healthcare record (EHR).

SpectralGPT: Spectral Remote Sensing Foundation Model.

The foundation model has recently garnered significant attention due to its potential to revolutionize the field of visual representation learning in a self-supervised manner. While most foundation models are tailored to effectively process RGB images for various visual tasks, there is a noticeable gap in research focused on spectral data, which offers valuable information for scene understanding, especially in remote sensing (RS) applications. To fill this gap, we created for the first time a universal RS foundation model, named SpectralGPT, which is purpose-built to handle spectral RS images using a novel 3D generative pretrained transformer (GPT).

The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances.

Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly what LBP impacts on the brain required further researches.

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy.

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is complex and not fully understood. Podocytes, glomerular endothelial cells (GECs), glomerular mesangial cells (GMCs) and renal tubular epithelial cells (TECs) play important roles in the normal function of glomerulus and renal tubules, and their injury is involved in the progression of DN.

Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity.

Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. In this review, an overview of the pharmacology, pharmacokinetics, and toxicity of scopoletin is provided. In addition, the prospects and outlook for future studies are appraised.

SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.

A growing amount of epidemiological evidence proposes diabetes mellitus (DM) to be an independent risk factor for osteoarthritis (OA). Sirtuin 3 (SIRT3), which is mainly located in mitochondria, belongs to the family of nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases and is involved in the physiological and pathological processes of cell regulation. The aim of this study was to investigate the effects of SIRT3 on diabetic OA and underlying mechanisms in the prevention of type 2 DM (T2DM)-induced articular cartilage damage.

A change in social participation affects cognitive function in middle-aged and older Chinese adults: analysis of a Chinese longitudinal study on aging (2011-2018).

Background: One of the biggest challenges facing older adults is cognitive decline and social participation has always been considered a protective factor. However, it is not clear whether social participation predicts cognitive function in this population, rather than depressive symptoms, self-reported health, and activities of daily life, with sufficient capacity to detect unique effects.

Methods: This study included adults aged 45 and above in China ( = 5,258) who participated in a large national older adult health survey and provided data from 2011, 2013, 2015, and 2018.

A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin-Based Drugs.

Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities in marine tunicate extracts. Herein, we introduce a new approach that integrates microbial and chemical synthesis to generate plitidepsin and its analogues. We screened a Tistrella strain library to identify a potent didemnin B producer, and then introduced a second copy of the didemnin biosynthetic gene cluster into its genome, resulting in a didemnin B titer of approximately 75 mg/L.