Protective effect of Tibetan medicine Qiwei Tiexie pills on liver injury induced by acetaminophen overdose: An integrated strategy of network pharmacology, metabolomics and transcriptomics.

Background: Drug-induced liver injury, particularly from acetaminophen (APAP), has emerged as a significant public health concern. Unfortunately, there is currently no effective treatment strategy available. Qiwei Tiexie pills (QWTX), a traditional Tibetan medicine, have demonstrated considerable clinical efficacy in treating various liver diseases.

Porous graphitic carbon nitride with high concentration of oxygen promotes photocatalytic H evolution.

Porous structure design and the content regulation of heteroelements have been proved to be effective strategies to boost photocatalytic H generation activity of graphitic carbon nitride (g-CN) based photocatalyst. Herein, a series of porous graphitic carbon nitride with high concentration of oxygen (g-CN-O) photocatalysts were synthesized polymerization process using colloidal SiO as oxygen source. The content of oxygen within the g-CN-O photocatalysts could be tuned by adjusting the amount of added colloidal SiO during the preparation procedure.

Effects of Osteocyte Shape on Fluid Flow and Fluid Shear Stress of the Loaded Bone.

This study was conducted to better understand the specific behavior of the intraosseous fluid flow. We calculated the number and distribution of bone canaliculi around the osteocytes based on the varying shapes of osteocytes. We then used these calculated parameters and other bone microstructure data to estimate the anisotropy permeability of the lacunar-canalicular network.

Machine Learning Approach to Enhance the Performance of MNP-Labeled Lateral Flow Immunoassay.

The use of magnetic nanoparticle (MNP)-labeled immunochromatography test strips (ICTSs) is very important for point-of-care testing (POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic signal from ICTSs, limiting the applications of POCT. In this study, an ultrasensitive multiplex biosensor was designed to overcome the limitations of capturing and normalization of the weak magnetic signal from MNPs on ICTSs.

Dielectric properties of human liver from 10 Hz to 100 MHz: normal liver, hepatocellular carcinoma, hepatic fibrosis and liver hemangioma.

The dielectric properties of human liver were determined by characterization of tissue absorption and coupling of electromagnetic energy in the electromagnetic field. In this study the ex-vivo dielectric properties of human hepatocellular carcinoma (well and moderately differentiated), liver hemangioma, hepatic fibrosis (stages S1 and S2), and normal liver tissue were measured and analyzed over the frequency range of 10 Hz to 100 MHz. The dielectric properties over the frequency range can reflect tissue information including biological macromolecules, vesicles, and cellular membrane; these information aids in distinguishing different physiological states and lesions.

Reliability of in vivo measurements of the dielectric properties of anisotropic tissue: a simulative study.

A simulative study was performed to measure the dielectric properties of anisotropic tissue using several in vivo and in vitro probes. COMSOL Multiphysics was selected to carry out the simulation. Five traditional probes and a newly designed probe were used in this study.